دورية أكاديمية
Mediating Role of Liver Dysfunction in the Association between Arsenic Exposure and Diabetes in Chinese Adults: A Nationwide Cross-Sectional Study of China National Human Biomonitoring (CNHBM) 2017–2018
| العنوان: | Mediating Role of Liver Dysfunction in the Association between Arsenic Exposure and Diabetes in Chinese Adults: A Nationwide Cross-Sectional Study of China National Human Biomonitoring (CNHBM) 2017–2018 |
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| المؤلفون: | Saisai Ji, Yingli Qu, Qi Sun, Feng Zhao, Yidan Qiu, Zheng Li, Yawei Li, Haocan Song, Miao Zhang, Wenli Zhang, Hui Fu, Jiayi Cai, Zhuona Zhang, Ying Zhu, Zhaojin Cao, Yuebin Lv, Xiaoming Shi |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Biochemistry, Genetics, Molecular Biology, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, mediation analyses showed, 90 ), respectively, serum alanine aminotransferase, alt mediated 4, 33 ), 45 ), serum alt, aspartate aminotransferase, urinary total, study suggested, sectional study, reported regarding, positively associated, past year, moderate arsenic, mediating role, mediating analysis, lowest quartile, liver dysfunction, liver disease, fourth quartiles |
| الوقت: | 1 |
| الوصف: | Inconsistent results have been reported regarding the association between low-to-moderate arsenic (As) exposure and diabetes. The effect of liver dysfunction on As-induced diabetes remains unclear. The cross-sectional study included 10,574 adults from 2017–2018 China National Human Biomonitoring. Urinary total As (TAs) levels were analyzed as markers of As exposure. Generalized linear mixed models and restricted cubic splines models were used to examine the relationships among TAs levels, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) concentrations, and diabetes prevalence. Mediating analysis was performed to assess whether liver dysfunction mediated the association between TAs and diabetes. Overall, the OR (95% CI) of diabetes in participants in the second, third, and fourth quartiles of TAs were 1.08 (0.88, 1.33), 1.17 (0.94, 1.45), and 1.52 (1.22, 1.90), respectively, in the fully adjusted models compared with those in the lowest quartile. Serum ALT was positively associated with TAs and diabetes. Additionally, mediation analyses showed that ALT mediated 4.32% of the association between TAs and diabetes in the overall population and 8.86% in the population without alcohol consumption in the past year. This study suggested that alleviating the hepatotoxicity of As could have implications for both diabetes and liver disease. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | https://figshare.com/articles/journal_contribution/Mediating_Role_of_Liver_Dysfunction_in_the_Association_between_Arsenic_Exposure_and_Diabetes_in_Chinese_Adults_A_Nationwide_Cross-Sectional_Study_of_China_National_Human_Biomonitoring_CNHBM_2017_2018/25104178Test |
| DOI: | 10.1021/acs.est.3c08718.s001 |
| الإتاحة: | https://doi.org/10.1021/acs.est.3c08718.s001Test https://figshare.com/articles/journal_contribution/Mediating_Role_of_Liver_Dysfunction_in_the_Association_between_Arsenic_Exposure_and_Diabetes_in_Chinese_Adults_A_Nationwide_Cross-Sectional_Study_of_China_National_Human_Biomonitoring_CNHBM_2017_2018/25104178Test |
| حقوق: | CC BY-NC 4.0 |
| رقم الانضمام: | edsbas.DE9BBE70 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/acs.est.3c08718.s001 |
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