دورية أكاديمية
UV-Accelerated Synthesis of Gold Nanoparticle–Pluronic Nanocomposites for X-ray Computed Tomography Contrast Enhancement
| العنوان: | UV-Accelerated Synthesis of Gold Nanoparticle–Pluronic Nanocomposites for X-ray Computed Tomography Contrast Enhancement |
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| المؤلفون: | Gomes, Deizilene, S B, Paterno, Leonardo, G, Santos, Aline, B S, Barbosa, Debora, P P, Holtz, Beatriz, M, Souza, Maysa, R, Moraes-Souza, Rafaianne, Q, Garay, Aisel, V, de Andrade, Laise, R, Sartoratto, Patricia, P C, Mertz, Damien, Volpato, Gustavo, T, Freitas, Sonia, M, Soler, Maria, a G |
| المساهمون: | Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | ISSN: 2073-4360 ; Polymers ; https://hal.science/hal-04287210Test ; Polymers, 2023, 15 (9), pp.2163. ⟨10.3390/polym15092163⟩. |
| بيانات النشر: | HAL CCSD MDPI |
| سنة النشر: | 2023 |
| المجموعة: | Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
| مصطلحات موضوعية: | gold nanoparticle Pluronic F127 nanocomposites UV accelerated synthesis X-ray computed tomography cytotoxicity maternal and fetal toxicity assays, gold nanoparticle, Pluronic F127, nanocomposites, UV accelerated synthesis, X-ray computed tomography, cytotoxicity, maternal and fetal toxicity assays, [CHIM]Chemical Sciences |
| الوصف: | Eco-friendly chemical methods using FDA-approved Pluronic F127 (PLU) block copolymer have garnered much attention for simultaneously forming and stabilizing Au nanoparticles (AuNPs). Given the remarkable properties of AuNPs for usage in various fields, especially in biomedicine, we performed a systematic study to synthesize AuNP-PLU nanocomposites under optimized conditions using UV irradiation for accelerating the reaction. The use of UV irradiation at 254 nm resulted in several advantages over the control method conducted under ambient light (control). The AuNP-PLU-UV nanocomposite was produced six times faster, lasting 10 min, and exhibited lower size dispersion than the control. A set of experimental techniques was applied to determine the structure and morphology of the produced nanocomposites as affected by the UV irradiation. The MTT assay was conducted to estimate IC50 values of AuNP-PLU-UV in NIH 3T3 mouse embryonic fibroblasts, and the results suggest that the sample is more compatible with cells than control samples. Afterward, in vivo maternal and fetal toxicity assays were performed in rats to evaluate the effect of AuNP-PLU-UV formulation during pregnancy. Under the tested conditions, the treatment was found to be safe for the mother and fetus. As a proof of concept or application, the synthesized Au:PLU were tested as contrast agents with an X-ray computed tomography scan (X-ray CT). |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-04287210; https://hal.science/hal-04287210Test; https://hal.science/hal-04287210/documentTest; https://hal.science/hal-04287210/file/polymers-15-02163-v2-1.pdfTest |
| DOI: | 10.3390/polym15092163 |
| الإتاحة: | https://doi.org/10.3390/polym15092163Test https://hal.science/hal-04287210Test https://hal.science/hal-04287210/documentTest https://hal.science/hal-04287210/file/polymers-15-02163-v2-1.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.DE731F7A |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/polym15092163 |
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