دورية أكاديمية
Water-soluble carboranyl-phthalocyanines for BNCT. Synthesis, characterization, and in vitro tests of the Zn(II)-nido-carboranyl-hexylthiophthalocyanine
| العنوان: | Water-soluble carboranyl-phthalocyanines for BNCT. Synthesis, characterization, and in vitro tests of the Zn(II)-nido-carboranyl-hexylthiophthalocyanine |
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| المؤلفون: | Pietrangeli, Daniela, Rosa, Angela, Pepe, Antonietta, ALTIERI, SAVERIO, BORTOLUSSI, SILVA, POSTUMA, IAN, PROTTI, NICOLETTA, FERRARI, CINZIA, CANSOLINO, LAURA, CLERICI, ANNA MARIA, Viola, Elisa, Donzello, Maria Pia, Ricciardi, Giampaolo |
| المساهمون: | Pietrangeli, Daniela, Rosa, Angela, Pepe, Antonietta, Altieri, Saverio, Bortolussi, Silva, Postuma, Ian, Protti, Nicoletta, Ferrari, Cinzia, Cansolino, Laura, Clerici, ANNA MARIA, Viola, Elisa, Donzello, Maria Pia, Ricciardi, Giampaolo |
| سنة النشر: | 2015 |
| المجموعة: | IRIS UNIPV (Università degli studi di Pavia) |
| مصطلحات موضوعية: | Boron, Cell culture, Cesium, Fluorescence, Imaging technique, Nuclear magnetic resonance spectroscopy, Quantum yield, Quenching, Radiography, Rat, Zinc Anti-cancer therapie, Boron neutron capture therapy, Fluorescence emission spectroscopy, Fluorescence quantum yield, Fluorescence quenching, Photophysical measurement, Solubility in water, UV-visible absorption |
| الوصف: | The zinc(II) complex of the octa-anionic 2,3,9,10,16,17,23,24-octakis-(7-methyl-7,8-dicarba-nido-undeca-boran-8-yl)hexyl-thio-6,13,20,27-phthalocyanine (nido-[ZnMCHESPc]Cs8, 7) has been obtained in the form of caesium salt through mild deboronation of the neutral precursor, the closo-[ZnMCHESPc] complex, 6, with CsF. 6 has been synthesized, in turn, by heating a finely ground mixture of the appropriate phthalonitrile and zinc(II) acetate at 180.0 °C. The complexes have been characterized by elemental analyses, FT-IR, UV-visible absorption and fluorescence emission spectroscopy, and their structures were assessed by (1)H, (13)C, (11)B, and two-dimensional homo- and hetero-correlated NMR spectroscopy experiments. 7 showed appreciable solubility in water solution, together with a marked tendency to aggregate. Aggregation of 7 in the hydrotropic medium resulted in significant fluorescence quenching. Instead, fluorescence quantum yields (Φ(F)) of 0.14 and 0.08, and singlet oxygen quantum yields (Φ(Δ)) of 0.63 and 0.24 were obtained for 6 and 7, respectively, in a DMF solution. In vitro boron neutron capture therapy (BNCT) experiments, employing boron imaging techniques as implemented in qualitative and quantitative neutron autoradiography methods, showed that 7 is capable of increasing the boron concentration of two selected cancerous cell lines, the DHD/K12/TRb of rat colon adenocarcinoma and UMR-106 of rat osteosarcoma, with the large-size Cs(+) counter-ions used to neutralize the negatively charged carborane polyhedra not presenting a significant obstacle to the process. Taken together, BNCT and photophysical measurement results indicated that 7 is potentially suitable for bimodal or multimodal anticancer therapy. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/25995094; info:eu-repo/semantics/altIdentifier/wos/WOS:000356056900018; volume:44; issue:24; firstpage:11021; lastpage:11028; numberofpages:8; journal:DALTON TRANSACTIONS; http://hdl.handle.net/11571/1102500Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84935034775 |
| DOI: | 10.1039/c5dt00394f |
| الإتاحة: | https://doi.org/10.1039/c5dt00394fTest http://hdl.handle.net/11571/1102500Test |
| رقم الانضمام: | edsbas.DE4D93EC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1039/c5dt00394f |
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