دورية أكاديمية
Worldwide Disseminated IncX4 Plasmid Carrying mcr-1 Arrives to Wild Mammal in Portugal
| العنوان: | Worldwide Disseminated IncX4 Plasmid Carrying mcr-1 Arrives to Wild Mammal in Portugal |
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| المؤلفون: | Dantas Palmeira, Josman, Cunha, Mónica V., Ferreira, Helena, Fonseca, Carlos, Tinoco Torres, Rita |
| بيانات النشر: | American Society for Microbiology |
| سنة النشر: | 2023 |
| المجموعة: | Universidade de Lisboa: repositório.UL |
| الوصف: | The mcr-1 gene spread is worldwide recognized as a public health threat at multidrug-resistant infections therapy level. Here, we report for the first time, to the best of our knowledge, the detection of the globally distributed IncX4 plasmid carrying mcr-1 (mcr-1/IncX4) in Escherichia coli isolated from a wild mammal in Portugal and Europe. This plasmid was found in a ST533 E. coli isolate with a multidrug-resistant profile, virulence potential, and possibly phylogenetically related to human isolates. Our work contributes to highlight the importance of antimicrobial resistance (AMR) surveillance in wildlife, an important compartment of the whole ecosystem often overlooked in the fight against AMR. IMPORTANCE Colistin resistance mediated by plasmids is recognized worldwide as an emergency problem connected with the whole ecosystem, since is well described in the interface of the human-animal-environment. The plasmid IncX4 is reported as one of the most prevalent plasmids harboring the gene mcr-1. On an European scale the plasmid IncX4 carrying mcr-1 has been described in humans, the environment, and animals, including wildlife, but only in wild birds. This study shows the first report of the plasmid IncX4 harboring mcr-1 in a wild mammal in Portugal and Europe, identified in a ST533 E. coli commensal that is, curiously, more related to isolates from humans than from livestock. Our findings show that the plasmid IncX4 harboring mcr-1 is well established in a colistin resistance drive embracing the whole ecosystem. ; info:eu-repo/semantics/publishedVersion |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | FCTEcoARUn: POCI-01-0145-FEDER-030310- funded by FEDER, through COMPETE2020-POCI; FCT CESAM (UIDP/50017/20201UIDB/50017/20201LA/P/0094/ 2020), cE3c (UIDB/00329/2020), BioISI (UIDB/04046/2020), and UCIBIO (UIDP/04378/ 20201UIDB/04378/2020); AgriFood-XXI I&D&I-project (NORTE-01-0145-FEDER-000041) ERDF through the NORTE-2020 and also thanks the project FERMOPSY (EXPL/SAU-NUT/0370/2021) funded FCT/MCTES; Dantas Palmeira J, V Cunha M, Ferreira H, Fonseca C, Tinoco Torres R. Worldwide Disseminated IncX4 Plasmid Carrying mcr-1 Arrives to Wild Mammal in Portugal. Microbiol Spectr. 2022 Dec 21;10(6):e0124522. doi:10.1128/spectrum.01245-22. Epub 2022 Nov 17. PMID: 36394330; PMCID: PMC9769835.; http://hdl.handle.net/10451/55873Test |
| DOI: | 10.1128/spectrum.01245-22 |
| الإتاحة: | https://doi.org/10.1128/spectrum.01245-22Test http://hdl.handle.net/10451/55873Test |
| حقوق: | openAccess ; http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.DE446D67 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1128/spectrum.01245-22 |
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