دورية أكاديمية
Corticosteroids for Bell's palsy (idiopathic facial paralysis)
| العنوان: | Corticosteroids for Bell's palsy (idiopathic facial paralysis) |
|---|---|
| المؤلفون: | Madhok, Vishnu B., Gagyor, Ildiko, Daly, Fergus, Somasundara, Dhruvashree, Sullivan, Michael, Gammie, Fiona, Sullivan, Frank |
| المصدر: | Madhok , V B , Gagyor , I , Daly , F , Somasundara , D , Sullivan , M , Gammie , F & Sullivan , F 2016 , ' Corticosteroids for Bell's palsy (idiopathic facial paralysis) ' , Cochrane Database of Systematic Reviews , no. 7 , CD001942 . https://doi.org/10.1002/14651858.CD001942.pub5Test |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Anti-Inflammatory Agents, Bell Palsy, Cortisone, Glucocorticoids, Humans, Methylprednisolone, Prednisolone, Prednisone, Randomized Controlled Trials as Topic, Recovery of Function, Vitamins |
| الوصف: | Background: Inflammation and oedema of the facial nerve are implicated in causing Bell's palsy. Corticosteroids have a potent anti-inflammatory action that should minimise nerve damage. This is an update of a review first published in 2002 and last updated in 2010. Objectives: To determine the effectiveness and safety of corticosteroid therapy in people with Bell's palsy. Search Methods: On 4 March 2016, we searched the Cochrane Neuromuscular Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE and LILACS. We reviewed the bibliographies of the randomised trials and contacted known experts in the field to identify additional published or unpublished trials. We also searched clinical trials registries for ongoing trials. Selection criteria: Randomised trials and quasi-randomised trials comparing different routes of administration and dosage schemes of corticosteroid or adrenocorticotrophic hormone therapy versus a control group receiving no therapy considered effective for this condition, unless the same therapy was given in a similar way to the experimental group. Data collection and analysis: We used standard Cochrane methodology. The main outcome of interest was incomplete recovery of facial motor function (i.e. residual facial weakness). Secondary outcomes were cosmetically disabling persistent sequelae, development of motor synkinesis or autonomic dysfunction (i.e. hemifacial spasm, crocodile tears) and adverse effects of corticosteroid therapy manifested during follow-up. Main results: We identified seven trials, with 895 evaluable participants for this review. All provided data suitable for the primary outcome meta-analysis. One of the trials was new since the last version of this Cochrane systematic review. Risk of bias in the older, smaller studies included some unclear- or high-risk assessments, whereas we deemed the larger studies at low risk of bias. Overall, 79/452 (17%) participants allocated to corticosteroids had incomplete recovery of facial motor ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://research-portal.st-andrews.ac.uk/en/researchoutput/corticosteroids-for-bells-palsy-idiopathic-facial-paralysisTest(5d4dbf93-f3e7-4d76-a8d9-7e326aeedbeb).html |
| DOI: | 10.1002/14651858.CD001942.pub5 |
| الإتاحة: | https://doi.org/10.1002/14651858.CD001942.pub5Test https://research-portal.st-andrews.ac.uk/en/researchoutput/corticosteroids-for-bells-palsy-idiopathic-facial-paralysisTest(5d4dbf93-f3e7-4d76-a8d9-7e326aeedbeb).html https://research-repository.st-andrews.ac.uk/bitstream/10023/11252/1/Sullivan_2016_CDSR_Corticosteroids_FinalPubVersion.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.DE2907F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/14651858.CD001942.pub5 |
|---|