دورية أكاديمية
Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.
| العنوان: | Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets. |
|---|---|
| المؤلفون: | Wain, Louise V, Shrine, Nick, Artigas, María Soler, Erzurumluoglu, A Mesut, Noyvert, Boris, Bossini-Castillo, Lara, Obeidat, Ma'en, Henry, Amanda P, Portelli, Michael A, Hall, Robert J, Billington, Charlotte K, Rimington, Tracy L, Fenech, Anthony G, John, Catherine, Blake, Tineka, Jackson, Victoria E, Allen, Richard J, Prins, Bram P, Campbell, Archie, Porteous, David J, Jarvelin, Marjo-Riitta, Wielscher, Matthias, James, Alan L, Hui, Jennie, Wareham, Nicholas J, Zhao, Jing Hua, Wilson, James F, Joshi, Peter K, Stubbe, Beate, Rawal, Rajesh, Schulz, Holger, Imboden, Medea, Probst-Hensch, Nicole M, Karrasch, Stefan, Gieger, Christian, Deary, Ian J, Harris, Sarah E, Marten, Jonathan, Rudan, Igor, Enroth, Stefan, Gyllensten, Ulf, Kerr, Shona M, Polasek, Ozren, Kähönen, Mika, Surakka, Ida, Vitart, Veronique, Hayward, Caroline, Lehtimäki, Terho, Raitakari, Olli T, Evans, David M, Henderson, A John, Pennell, Craig E, Wang, Carol A, Sly, Peter D, Wan, Emily S, Busch, Robert, Hobbs, Brian D, Litonjua, Augusto A, Sparrow, David W, Gulsvik, Amund, Bakke, Per S, Crapo, James D, Beaty, Terri H, Hansel, Nadia N, Mathias, Rasika A, Ruczinski, Ingo, Barnes, Kathleen C, Bossé, Yohan, Joubert, Philippe, van den Berge, Maarten, Brandsma, Corry-Anke, Paré, Peter D, Sin, Don D, Nickle, David C, Hao, Ke, Gottesman, Omri, Dewey, Frederick E, Bruse, Shannon E, Carey, David J, Kirchner, H Lester, Jonsson, Stefan, Thorleifsson, Gudmar, Jonsdottir, Ingileif, Gislason, Thorarinn, Stefansson, Kari, Schurmann, Claudia, Nadkarni, Girish, Bottinger, Erwin P, Loos, Ruth J F, Walters, Robin G, Chen, Zhengming, Millwood, Iona Y, Vaucher, Julien, Kurmi, Om P, Li, Liming, Hansell, Anna L, Brightling, Chris, Zeggini, Eleftheria, Cho, Michael H, Silverman, Edwin K, Sayers, Ian, Trynka, Gosia, Morris, Andrew P, Strachan, David P, Hall, Ian P, Tobin, Martin D |
| المساهمون: | 1 Univ Leicester, Dept Hlth Sci, Leicester, Leics, England Show the Organization-Enhanced name(s) 2 Glenfield Hosp, Natl Inst Hlth Res, Leicester Resp Biomed Res Unit, Leicester, Leics, England Show the Organization-Enhanced name(s) 3 Wellcome Trust Sanger Inst, Hinxton, England Show the Organization-Enhanced name(s) 4 Univ British Columbia, Ctr Heart Lung Innovat, St Pauls Hosp, Vancouver, BC, Canada Show the Organization-Enhanced name(s) 5 Univ Nottingham, Div Resp Med, Nottingham, England Show the Organization-Enhanced name(s) 6 Univ Malta, Dept Clin Pharmacol & Therapeut, Msida, Malta Show the Organization-Enhanced name(s) 7 Wellcome Trust Sanger Inst, Dept Human Genet, Hinxton, England Show the Organization-Enhanced name(s) 8 Univ Edinburgh, Inst Genet & Mol Med, Ctr Genom & Expt Med, Med Genet Sect, Edinburgh, Midlothian, Scotland Show the Organization-Enhanced name(s) 9 Univ Edinburgh, Ctr Genom & Expt Med, Generat Scotland, Edinburgh, Midlothian, Scotland Show the Organization-Enhanced name(s) 10 Imperial Coll London, Sch Publ Hlth, MRC PHE Ctr Environm & Hlth, Dept Epidemiol & Biostat, London, England Show the Organization-Enhanced name(s) 11 Univ Oulu, Ctr Life Course Hlth Res, Fac Med, Oulu, Finland Show the Organization-Enhanced name(s) 12 Univ Oulu, Bioctr Oulu, Oulu, Finland Show the Organization-Enhanced name(s) 13 Oulu Univ Hosp, Unit Primary Care, Oulu, Finland Show the Organization-Enhanced name(s) 14 Sir Charles Gairdner Hosp, Busselton Populat Med Res Inst, Nedlands, WA, Australia Show the Organization-Enhanced name(s) 15 Sir Charles Gairdner Hosp, Dept Pulm Physiol & Sleep Med, Nedlands, WA, Australia Show the Organization-Enhanced name(s) 16 Univ Western Australia, Sch Med & Pharmacol, Crawley, WA, Australia Show the Organization-Enhanced name(s) 17 Univ Western Australia, Sch Populat Hlth, Crawley, WA, Australia 18 Sir Charles Gairdner Hosp, PathWest Lab Med Western Australia, Crawley, WA, Australia Show the Organization-Enhanced name(s) 19 Univ Western Australia, Sch Pathol & Lab Med, Crawley, WA, Australia Show the Organization-Enhanced name(s) 20 Univ Cambridge, Sch Clin Med, MRC Epidemiol Unit, Inst Metab Sci, Cambridge Biomed Campus, Cambridge, England Show the Organization-Enhanced name(s) 21 Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Edinburgh, Midlothian, Scotland Show the Organization-Enhanced name(s) 22 Univ Edinburgh, Inst Genet & Mol Med, MRC, Human Genet Unit, Edinburgh, Midlothian, Scotland 23 Univ Med Greifswald, Dept Internal Med Cardiol Intens Care Pulm Med &, Greifswald, Germany Show the Organization-Enhanced name(s) 24 Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol 2, Res Unit Mol Epidemiol, Neuherberg, Germany Show the Organization-Enhanced name(s) 25 Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol 1, Neuherberg, Germany 26 German Ctr Lung Res, Comprehens Pneumol Ctr Munich CPC M, Neuherberg, Germany Show the Organization-Enhanced name(s) 27 Swiss Trop & Publ Hlth Inst, Basel, Switzerland Show the Organization-Enhanced name(s) 28 Univ Basel, Basel, Switzerland Show the Organization-Enhanced name(s) 29 Ludwig Maximilians Univ Munchen, Inst & Outpatient Clin Occupat Social & Environm, Munich, Germany Show the Organization-Enhanced name(s) 30 Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland Show the Organization-Enhanced name(s) 31 Univ Edinburgh, Dept Psychol, Edinburgh, Midlothian, Scotland Show the Organization-Enhanced name(s) 32 Uppsala Univ, Sci Life Lab, Dept Immunol Genet & Pathol, Uppsala, Sweden Show the Organization-Enhanced name(s) 33 Univ Split, Sch Med, Split, Croatia Show the Organization-Enhanced name(s) 34 Univ Tampere, Dept Clin Physiol, Tampere, Finland Show the Organization-Enhanced name(s) 35 Tampere Univ Hosp, Tampere, Finland Show the Organization-Enhanced name(s) 36 Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland Show the Organization-Enhanced name(s) 37 Natl Inst Hlth & Welf THL, Helsinki, Finland Show the Organization-Enhanced name(s) 38 Univ Tampere, Fimlab Labs, Dept Clin Chem, Tampere, Finland Show the Organization-Enhanced name(s) 39 Univ Tampere, Sch Med, Tampere, Finland Show the Organization-Enhanced name(s) 40 Univ Tampere, Sch Med, Dept Clin Chem, Tampere, Finland Show the Organization-Enhanced name(s) 41 Turku Univ Hosp, Dept Clin Physiol & Nucl Med, Turku, Finland Show the Organization-Enhanced name(s) 42 Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland Show the Organization-Enhanced name(s) 43 Univ Queensland, Translat Res Inst, Diamantina Inst, Brisbane, Qld, Australia Show the Organization-Enhanced name(s) 44 Univ Bristol, MRC Integrat Epidemiol Unit, Bristol, Avon, England Show the Organization-Enhanced name(s) 45 Univ Bristol, Sch Social & Community Med, Bristol, Avon, England Show the Organization-Enhanced name(s) 46 Univ Western Australia, Sch Womens & Infants Hlth, Perth, WA, Australia Show the Organization-Enhanced name(s) 47 Univ Queensland, Fac Med, Child Hlth Res Ctr, Brisbane, Qld, Australia Show the Organization-Enhanced name(s) 48 Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA Show the Organization-Enhanced name(s) 49 Brigham & Womens Hosp, Div Pulm & Crit Care Med, 75 Francis St, Boston, MA 02115 USA Show the Organization-Enhanced name(s) 50 VA Boston Healthcare Syst, Boston, MA USA Show the Organization-Enhanced name(s) 51 Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA Show the Organization-Enhanced name(s) 52 Univ Bergen, Dept Clin Sci, Bergen, Norway Show the Organization-Enhanced name(s) 53 Natl Jewish Hlth, Denver, CO USA Show the Organization-Enhanced name(s) 54 Natl Jewish Hlth, Div Pulm Crit Care & Sleep Med, Denver, CO USA Show the Organization-Enhanced name(s) 55 Johns Hopkins Univ, Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA Show the Organization-Enhanced name(s) 56 Johns Hopkins Univ, Sch Med, Pulm & Crit Care Med, Baltimore, MD USA Show the Organization-Enhanced name(s) 57 Johns Hopkins Univ, Sch Med, Div Allergy & Clin Immunol, Baltimore, MD USA Show the Organization-Enhanced name(s) 58 Johns Hopkins Univ, Dept Biostat, Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA Show the Organization-Enhanced name(s) 59 Univ Colorado, Sch Med, Dept Med, Div Biomed Informat & Personalized Med, Anschutz Med Campus, Aurora, CO USA Show the Organization-Enhanced name(s) 60 Univ Laval, Dept Mol Med, Quebec City, PQ, Canada Show the Organization-Enhanced name(s) 61 Univ Laval, Inst Univ Cardiol & Pneumol Quebec, Quebec City, PQ, Canada Show the Organization-Enhanced name(s) 62 Univ Laval, Dept Mol Biol Med Biochem & Pathol, Quebec City, PQ, Canada Show the Organization-Enhanced name(s) 63 Univ Groningen, Univ Med Ctr Groningen, Dept Pulmonol, GRIAC Res Inst, Groningen, Netherlands Show the Organization-Enhanced name(s) 64 Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Med Biol, GRIAC Res Inst, Groningen, Netherlands Show the Organization-Enhanced name(s) 65 Univ British Columbia, Dept Med, Resp Div, Vancouver, BC, Canada Show the Organization-Enhanced name(s) 66 Merck Res Labs, Genet & Pharmacogen, Boston, MA USA 67 Icahn Sch Med Mt Sinai, Icahn Inst Genom & Multiscale Biol, New York, NY 10029 USA Show the Organization-Enhanced name(s) 68 Regeneron Pharmaceut Inc, Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA 69 Geisinger Hlth Syst, Danville, PA USA 70 deCODE Genet Amgen Inc, Reykjavik, Iceland Show the Organization-Enhanced name(s) 71 Univ Iceland, Fac Med, Sch Hlth Sci, Reykjavik, Iceland Show the Organization-Enhanced name(s) 72 Landspitali Univ Hosp Reykjavik, Dept Resp Med & Sleep, Reykjavik, Iceland 73 Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA 74 Icahn Sch Med Mt Sinai, Genet Obes & Related Metab Traits Program, New York, NY 10029 USA 75 Icahn Sch Med Mt Sinai, Mindich Child Hlth Dev Inst, New York, NY 10029 USA Show the Organization-Enhanced name(s) 76 Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Oxford, England Show the Organization-Enhanced name(s) 77 Univ Oxford, Nuffield Dept Populat Hlth, Epidemiol Studies Unit CTSU, Oxford, England Show the Organization-Enhanced name(s) 78 Univ Oxford, MRC, Populat Hlth Res Unit, Oxford, England Show the Organization-Enhanced name(s) 79 Chinese Acad Med Sci, Beijing, Peoples R China Show the Organization-Enhanced name(s) 80 Peking Univ, Hlth Sci Ctr, Dept Epidemiol & Biostat, Beijing, Peoples R China Show the Organization-Enhanced name(s) 81 Imperial Coll London, Sch Publ Hlth, MRC PHE Ctr Environm & Hlth, UK Small Area Hlth Stat Unit, London, England Show the Organization-Enhanced name(s) 82 Imperial Coll Healthcare NHS Trust, St Marys Hosp, London, England Show the Organization-Enhanced name(s) 83 Univ Leicester, Inst Lung Hlth, Dept Infect Inflammat & Immun, Leicester, Leics, England Show the Organization-Enhanced name(s) 84 Univ Liverpool, Dept Biostat, Liverpool, Merseyside, England Show the Organization-Enhanced name(s) 85 St Georges Univ London, Populat Hlth Res Inst, London, England |
| بيانات النشر: | Nature Publishing Group |
| سنة النشر: | 2017 |
| المجموعة: | Hirsla - Landspítali University Hospital research archive |
| مصطلحات موضوعية: | Langvinn lungnateppa, PAD12, Pulmonary Disease, Chronic Obstructive, Genome-Wide Association Study |
| الوصف: | Chronic obstructive pulmonary disease (COPD) is characterized by reduced lung function and is the third leading cause of death globally. Through genome-wide association discovery in 48,943 individuals, selected from extremes of the lung function distribution in UK Biobank, and follow-up in 95,375 individuals, we increased the yield of independent signals for lung function from 54 to 97. A genetic risk score was associated with COPD susceptibility (odds ratio per 1 s.d. of the risk score (∼6 alleles) (95% confidence interval) = 1.24 (1.20-1.27), P = 5.05 × 10(-49)), and we observed a 3.7-fold difference in COPD risk between individuals in the highest and lowest genetic risk score deciles in UK Biobank. The 97 signals show enrichment in genes for development, elastic fibers and epigenetic regulation pathways. We highlight targets for drugs and compounds in development for COPD and asthma (genes in the inositol phosphate metabolism pathway and CHRM3) and describe targets for potential drug repositioning from other clinical indications. ; Medical Research Council (MRC) National Institute for Health Research (NIHR) |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1546-1718 28166213 |
| العلاقة: | http://www.nature.com/ng/journal/v49/n3/pdf/ng.3787.pdfTest; Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets. 2017, 49 (3):416-425 Nat. Genet.; http://hdl.handle.net/2336/620143Test; Nature genetics |
| DOI: | 10.1038/ng.3787 |
| الإتاحة: | https://doi.org/10.1038/ng.3787Test http://hdl.handle.net/2336/620143Test |
| حقوق: | Archived with thanks to Nature genetics ; Closed - Lokað |
| رقم الانضمام: | edsbas.DD4847D7 |
| قاعدة البيانات: | BASE |
| تدمد: | 15461718 28166213 |
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| DOI: | 10.1038/ng.3787 |