دورية أكاديمية
Explaining variability in early stages of [18F]-flortaucipir tau-PET binding: Focus on sex differences
| العنوان: | Explaining variability in early stages of [18F]-flortaucipir tau-PET binding: Focus on sex differences |
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| المؤلفون: | Bachmann, Dario, id_orcid:0 000-0002-2863-537X, Buchmann, Andreas, Studer, Sandro, Saake, Antje, Rauen, Katrin, Gruber, Esmeralda, Nitsch, Roger M., Hock, Christoph, Gietl, Anton, Treyer, Valerie |
| المصدر: | Alzheimer's and Dementia. Diagnosis, Assessment and Disease Monitoring, 16 (1) |
| بيانات النشر: | Wiley |
| سنة النشر: | 2024 |
| المجموعة: | ETH Zürich Research Collection |
| مصطلحات موضوعية: | age at menopause, Alzheimer's disease, amyloid pathology, hormone replacement therapy, off-target binding, tau pathology |
| الوصف: | Introduction: Female sex is associated with increased [18F]-flortaucipir signal, which may be affected by amyloid pathology, age, and off-target binding in skull and meninges. Methods: In this cross-sectional study comprising 52 females and 52 matched males, we examined sex-related differences in regional tau-positron emission tomography (PET) with and without considering off-target binding. We assessed the respective contributions of sex, age, amyloid-PET burden, and off-target binding to tau-PET signal. We explored associations between age at menopause and hormone replacement therapy (HRT) use with regional tau-PET signals. Results: Female sex was associated with increased regional tau both independently and interactively with amyloid, but amyloid-independent associations were largely reduced when controlling for off-target binding. Age but not age*sex interactions explained a small but significant amount of tau-PET signal in temporoparietal regions. Considering the sample size and limited range of amyloid-PET burden, no clear associations between regional tau-PET signals and age at menopause or HRT use could be found. Discussion: Female sex is associated with increased [18F]-flortaucipir signal mainly through its interaction with amyloid. ; ISSN:2352-8729 |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/application/pdf |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/001180352000001; http://hdl.handle.net/20.500.11850/665230Test |
| DOI: | 10.3929/ethz-b-000665230 |
| الإتاحة: | https://doi.org/20.500.11850/665230Test https://doi.org/10.3929/ethz-b-000665230Test https://doi.org/10.1002/dad2.12565Test https://hdl.handle.net/20.500.11850/665230Test |
| حقوق: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by-nc-nd/4.0Test/ ; Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International |
| رقم الانضمام: | edsbas.DD45B652 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3929/ethz-b-000665230 |
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