التفاصيل البيبلوغرافية
| العنوان: |
Spatial targeted delivery of riboflavin with a controlled corneal iontophoresis delivery system in theranostic‐guided UV‐A light photo‐therapy |
| المؤلفون: |
Lombardo, Marco, Serrao, Sebastiano, Bernava, Giuseppe Massimo, Lombardo, Giuseppe |
| المساهمون: |
Lazio Innova |
| المصدر: |
Journal of Biophotonics ; ISSN 1864-063X 1864-0648 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2024 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Seven human donor eye globes underwent corneal cross‐linking using theranostic UV‐A device with accessory corneal iontophoresis system for patterned delivery of a 0.22% riboflavin solution. Theranostic‐guided UV‐A light illumination assessed riboflavin distribution and treated corneas at 10 mW/cm 2 for 9 min with a 5.0‐mm beam size. Corneal topography maps were taken at baseline and 2‐h post‐treatment. Analysis utilized corneal topography elevation data, with results showing controlled riboflavin delivery led to a consistent gradient, with 40% higher levels centrally (248 ± 79 μg/cm 3 ) than peripherally (180 ± 72 μg/cm 3 at ±2.5 mm from the center). Theranostic‐guided UV‐A light irradiation resulted in significant changes in corneal topography, with a decrease in best‐fit sphere value (−0.7 ± 0.2 D; p < 0.001) and consistent downward shift in corneal elevation map (−11.7 ± 3.7 μm). The coefficient of variation was 2.5%, indicating high procedure performance in achieving significant and reliable corneal flattening. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1002/jbio.202400068 |
| الإتاحة: |
https://doi.org/10.1002/jbio.202400068Test |
| حقوق: |
http://onlinelibrary.wiley.com/termsAndConditions#vorTest |
| رقم الانضمام: |
edsbas.DD445110 |
| قاعدة البيانات: |
BASE |
