دورية أكاديمية
Lower Limb Deformity and Gait Deviations Among Adolescents and Adults With X-Linked Hypophosphatemia
| العنوان: | Lower Limb Deformity and Gait Deviations Among Adolescents and Adults With X-Linked Hypophosphatemia |
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| المؤلفون: | Gabriel T. Mindler, Andreas Kranzl, Alexandra Stauffer, Roland Kocijan, Rudolf Ganger, Christof Radler, Gabriele Haeusler, Adalbert Raimann |
| المصدر: | Frontiers in Endocrinology, Vol 12 (2021) |
| بيانات النشر: | Frontiers Media S.A. |
| سنة النشر: | 2021 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | XLH, gait analysis, gait deviations, hypophosphatemia, deformity, pseudofracture, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| الوصف: | BackgroundX-linked hypophosphatemia (XLH) is a rare genetic disorder characterized by lower limb deformity, gait and joint problems, and pain. Hence, quality of life is substantially impaired. This study aimed to assess lower limb deformity, specific radiographic changes, and gait deviations among adolescents and adults with XLH.DesignData on laboratory examination and gait analysis results were analyzed retrospectively. Deformities, osteoarthritis, pseudofractures, and enthesopathies on lower limb radiographs were investigated. Gait analysis findings were compared between the XLH group and the control group comprising healthy adults.Patients and ControlsRadiographic outcomes were assessed retrospectively in 43 patients with XLH (28 female, 15 male). Gait analysis data was available in 29 patients with confirmed XLH and compared to a healthy reference cohort (n=76).ResultsPatients with XLH had a lower gait quality compared to healthy controls (Gait deviation index GDI 65.9% +/- 16.2). About 48.3% of the study population presented with a greater lateral trunk lean, commonly referred to as waddling gait. A higher BMI and mechanical axis deviation of the lower limbs were associated with lower gait scores and greater lateral trunk lean. Patients with radiologic signs of enthesopathies had a lower GDI.ConclusionsThis study showed for the first time that lower limb deformity, BMI, and typical features of XLH such as enthesopathies negatively affected gait quality among adolescents and adults with XLH. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1664-2392 |
| العلاقة: | https://www.frontiersin.org/articles/10.3389/fendo.2021.754084/fullTest; https://doaj.org/toc/1664-2392Test; https://doaj.org/article/699f627be92d429ea72edb33b462481eTest |
| DOI: | 10.3389/fendo.2021.754084 |
| الإتاحة: | https://doi.org/10.3389/fendo.2021.754084Test https://doaj.org/article/699f627be92d429ea72edb33b462481eTest |
| رقم الانضمام: | edsbas.DCD24A6E |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16642392 |
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| DOI: | 10.3389/fendo.2021.754084 |