دورية أكاديمية
Plasma-derived proteomic biomarkers in human leukocyte antigen-haploidentical or human leukocyte antigen-matched bone marrow transplantation using post-transplantation cyclophosphamide
العنوان: | Plasma-derived proteomic biomarkers in human leukocyte antigen-haploidentical or human leukocyte antigen-matched bone marrow transplantation using post-transplantation cyclophosphamide |
---|---|
المؤلفون: | Kanakry, Christopher G., Bakoyannis, Giorgos, Perkins, Susan M., McCurdy, Shannon R., Vulic, Ante, Warren, Edus H., Daguindau, Etienne, Olmsted, Taylor, Mumaw, Christen, Towlerton, Andrea M.H., Cooke, Kenneth R., O’Donnell, Paul V., Symons, Heather J., Paczesny, Sophie, Luznik, Leo |
المساهمون: | Biostatistics, School of Public Health |
المصدر: | PMC |
بيانات النشر: | Ferrata Storti Foundation |
سنة النشر: | 2017 |
المجموعة: | Indiana University - Purdue University Indianapolis: IUPUI Scholar Works |
مصطلحات موضوعية: | Biochemical markers, Proteomics, Bone marrow -- Transplantation, Cyclophosphamide, Graft versus host disease |
الوصف: | Recent studies have suggested that plasma-derived proteins may be potential biomarkers relevant for graft-versus-host disease and/or non-relapse mortality occurring after allogeneic blood or marrow transplantation. However, none of these putative biomarkers have been assessed in patients treated either with human leukocyte antigen-haploidentical blood or marrow transplantation or with post-transplantation cyclophosphamide, which has been repeatedly associated with low rates of severe acute graft-versus-host disease, chronic graft-versus-host disease, and non-relapse mortality. We explored whether seven of these plasma-derived proteins, as measured by enzyme-linked immunosorbent assays, were predictive of clinical outcomes in post-transplantation cyclophosphamide-treated patients using plasma samples collected at serial predetermined timepoints from patients treated on prospective clinical studies of human leukocyte antigen-haploidentical (n=58; clinicaltrials.gov Identifier: 00796562) or human leukocyte antigen-matched-related or -unrelated (n=100; clinicaltrials.gov Identifiers: 00134017 and 00809276) T-cell-replete bone marrow transplantation. Day 30 levels of interleukin-2 receptor α, tumor necrosis factor receptor 1, serum STimulation-2 (IL1RL1 gene product), and regenerating islet-derived 3-α all had high areas under the curve of 0.74–0.97 for predicting non-relapse mortality occurrence by 3 months post-transplant in both the human leukocyte antigen-matched and human leukocyte antigen-haploidentical cohorts. In both cohorts, all four of these proteins were also predictive of subsequent non-relapse mortality occurring by 6, 9, or 12 months post-transplant and were significantly associated with non-relapse mortality in univariable analyses. Furthermore, day 30 elevations of interleukin-2 receptor α were associated with grade II–IV and III–IV acute graft-versus-host disease occurring after day 30 in both cohorts. These data confirm that plasma-derived proteins previously assessed in other transplantation ... |
نوع الوثيقة: | article in journal/newspaper |
وصف الملف: | application/pdf |
اللغة: | English |
العلاقة: | Haematologica; Kanakry, C. G., Bakoyannis, G., Perkins, S. M., McCurdy, S. R., Vulic, A., Warren, E. H., … Luznik, L. (2017). Plasma-derived proteomic biomarkers in human leukocyte antigen-haploidentical or human leukocyte antigen-matched bone marrow transplantation using post-transplantation cyclophosphamide. Haematologica, 102(5), 932–940. http://doi.org/10.3324/haematol.2016.152322Test; https://hdl.handle.net/1805/14848Test |
الإتاحة: | https://doi.org/10.3324/haematol.2016.152322Test https://hdl.handle.net/1805/14848Test |
حقوق: | Attribution-NonCommercial 3.0 United States ; http://creativecommons.org/licenses/by-nc/3.0/usTest/ |
رقم الانضمام: | edsbas.DCB6B463 |
قاعدة البيانات: | BASE |
الوصف غير متاح. |