التفاصيل البيبلوغرافية
| العنوان: |
Stereoconvergent Approach to the Enantioselective Construction of α‐Quaternary Alcohols by Radical Epoxide Allylation |
| المؤلفون: |
Höthker, Sebastian, Plato, Annika, Grimme, Stefan, Qu, Zheng‐Wang, Gansäuer, Andreas |
| المساهمون: |
Deutsche Forschungsgemeinschaft, Jürgen Manchot Stiftung |
| المصدر: |
Angewandte Chemie ; volume 136, issue 29 ; ISSN 0044-8249 1521-3757 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2024 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
We describe a highly stereoconvergent radical epoxide allylation towards diastereomerically and enantiomerically enriched α ‐quaternary alcohols in two steps from olefins. Our approach combines the stereospecifity and enantioselectivity of the Shi epoxidation with the unprecedented Ti(III)‐promoted intramolecular radical group transfer allylation of epoxides. A directional isomerization step via configurationally labile radical intermediates enables the selective preparation of all‐carbon quaternary stereocenters in a unique fashion. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1002/ange.202405911 |
| الإتاحة: |
https://doi.org/10.1002/ange.202405911Test |
| حقوق: |
http://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: |
edsbas.DCABD42 |
| قاعدة البيانات: |
BASE |
