دورية أكاديمية
The glucocorticoid PYED-1 disrupts mature biofilms of Candida spp. and inhibits hyphal development in Candida albicans
| العنوان: | The glucocorticoid PYED-1 disrupts mature biofilms of Candida spp. and inhibits hyphal development in Candida albicans |
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| المؤلفون: | Esposito A., Migliaccio A., Iula V. D., Zarrilli R., Guaragna A., De Gregorio E. |
| المساهمون: | Esposito, A., Migliaccio, A., Iula, V. D., Zarrilli, R., Guaragna, A., De Gregorio, E. |
| سنة النشر: | 2021 |
| المجموعة: | IRIS Università degli Studi di Napoli Federico II |
| مصطلحات موضوعية: | Anti-biofilm agent, Antifungal agent, Candida spp, Glucocorticoid |
| الوصف: | Invasive Candida infections have become a global public health problem due to the increase of Candida species resistant against antifungal therapeutics. The glucocorticoid PYED-1 (pregnadiene-11-hydroxy-16α,17α-epoxy-3,20-dione-1) has antimicrobial activity against various bacterial taxa. Consequently, it might be considered for the treatment of Candida infections. The antifungal activity of PYED-1 was evaluated against several fungal strains that were representative of the five species that causes the majority of Candida infections—namely, Candida albicans, Candida glabrata, Candida tropicalis, Candida parapsilosis and Candida krusei. PYED-1 exhibited a weak antifungal activity and a fungistatic effect on all five Candida species. On the other hand, PYED-1 exhibited a good antibiofilm activity, and was able to eradicate the preformed biofilms of all Candida species analyzed. Moreover, PYED-1 inhibited germ tube and hyphae formation of C. albicans and reduced adhesion of C. albicans to abiotic surfaces by up to 30%. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/WOS:000727684000001; volume:10; issue:11; firstpage:1396; numberofpages:9; journal:ANTIBIOTICS; http://hdl.handle.net/11588/863605Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85119627745 |
| DOI: | 10.3390/antibiotics10111396 |
| الإتاحة: | https://doi.org/10.3390/antibiotics10111396Test http://hdl.handle.net/11588/863605Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.DC93E8E |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/antibiotics10111396 |
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