دورية أكاديمية
Altered pattern of monocyte differentiation and monocyte-derived TGF-β1 in severe asthma
| العنوان: | Altered pattern of monocyte differentiation and monocyte-derived TGF-β1 in severe asthma |
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| المؤلفون: | Hung, Chih-Hsing, Wang, Chin-Chou, Suen, Jau-Ling, Sheu, Chau-Chyun, Kuo, Chang-Hung, Liao, Wei-Ting, Yang, Yi-Hsin, Wu, Chao-Chien, Leung, Sum-Yee, Lai, Ruay-Sheng, Lin, Chi-Cheng, Wei, Yu-Feng, Lee, Chong-Yeh, Huang, Ming-Shyan, Huang, Shau-Ku |
| المصدر: | Scientific Reports ; volume 8, issue 1 ; ISSN 2045-2322 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Multidisciplinary |
| الوصف: | CD14 + monocytes contain precursors for macrophages and fibrocytes, known to be involved in regulating airway remodeling in human asthma and distinguishable by the PM-2K marker. We sought to identify circulating subsets of PM-2K + macrophage-like cells and evaluate their relationships to lung function, severity and control status. Circulating PM-2K + macrophage-like cells and fibrocytes could be identified and distinguished between normal individuals ( N = 152) and asthmatic subjects ( N = 133) using multi-parametric flow cytometry. PM-2K + macrophage-like cells were found to be significantly lower in asthmatic subjects, particularly noted for the CD14 − PM-2K + subset and PM-2K + CCR7 − CD86 + cells in subjects with poor lung function (FEV%/FVC% < 80%) as compared to those of normal subjects and asthmatics with normal lung function, whereas the frequency of fibrocytes was higher in asthmatics and the CCR7 − CD86 + subset distribution was significantly different in subjects with varying severity. Moreover, exogenous transforming growth factor beta 1 (TGF-β1) was found to inhibit the generation of PM-2K + macrophage - like cells, but promote the growth of fibrocytes, from CD14 + monocytes , and monocyte-derived TGF-β1 was found to correlate with the lung function, severity and control status in asthmatic patients. Collectively, aberrant differentiation of monocytes into PM-2K + macrophage-like cell subsets and fibrocytes, together with increased monocyte-derived TGF-β1, characterized patients with severe asthma. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41598-017-19105-z |
| الإتاحة: | https://doi.org/10.1038/s41598-017-19105-zTest https://www.nature.com/articles/s41598-017-19105-zTest https://www.nature.com/articles/s41598-017-19105-z.pdfTest |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.DC922B5C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41598-017-19105-z |
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