دورية أكاديمية
Rheumatoid Arthritis Flares After Total Hip and Total Knee Arthroplasty: Outcomes at One Year
| العنوان: | Rheumatoid Arthritis Flares After Total Hip and Total Knee Arthroplasty: Outcomes at One Year |
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| المؤلفون: | Goodman, S. M., Mirza, S. Z., DiCarlo, E. F., Pearce-Fisher, D., Zhang, M., Mehta, B., Donlin, L. T., Bykerk, V. P., Figgie, M. P., Orange, D. E. |
| المصدر: | Journal Articles |
| بيانات النشر: | Donald and Barbara Zucker School of Medicine Academic Works |
| سنة النشر: | 2020 |
| المجموعة: | Hofstra Northwell Academic Works (Hofstra Northwell School of Medicine) |
| مصطلحات موضوعية: | Medical Molecular Biology |
| الوصف: | © 2019, American College of Rheumatology Objective: Most patients with rheumatoid arthritis (RA) undergoing total hip arthroplasty (THA) and total knee arthroplasty (TKA) have active RA and report postoperative flares; whether RA disease activity or flares increase the risk of worse pain and function scores 1 year later is unknown. Methods: Patients with RA were enrolled before THA/TKA. Patient-reported outcomes, including the Hip disability and Osteoarthritis Outcome Score (HOOS)/Knee Injury and Osteoarthritis Outcome Score (KOOS) and physician assessments of disease characteristics and activity (Disease Activity Score in 28 joints [DAS28] and Clinical Disease Activity Index), were collected before surgery. Patient-reported outcomes were repeated at 1 year. Postoperative flares were identified using the RA Flare Questionnaire weekly for 6 weeks and were defined by concordance between patient report plus physician assessment. We compared baseline characteristics and HOOS/KOOS scores using 2-sample t-test/Wilcoxon's rank sum test as well as chi-square/Fisher's exact tests. We used multivariate linear and logistic regression to determine the association of baseline characteristics, disease activity, and flares with 1-year outcomes. Results: One-year HOOS/KOOS scores were available for 122 patients (56 with THA and 66 with TKA). Although HOOS/KOOS pain was worse for patients who experienced a flare within 6 weeks of surgery, absolute improvement was not different. In multivariable models, baseline DAS28 predicted 1-year HOOS/KOOS pain and function; each 1-unit increase in DAS28 worsened 1-year pain by 2.41 (SE 1.05; P = 0.02) and 1-year function by 4.96 (SE 1.17; P = 0.0001). Postoperative flares were not independent risk factors for pain or function scores. Conclusion: Higher disease activity increased the risk of worse pain and function 1 year after arthroplasty, but postoperative flares did not. |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| العلاقة: | https://academicworks.medicine.hofstra.edu/publications/7156Test |
| DOI: | 10.1002/acr.24091 |
| الإتاحة: | https://doi.org/10.1002/acr.24091Test https://academicworks.medicine.hofstra.edu/publications/7156Test |
| رقم الانضمام: | edsbas.DC87203D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/acr.24091 |
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