دورية أكاديمية
Cancer Incidence Among Those Initiating Insulin Therapy With Glargine Versus Human NPH Insulin
| العنوان: | Cancer Incidence Among Those Initiating Insulin Therapy With Glargine Versus Human NPH Insulin |
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| المؤلفون: | Sturmer, T., Marquis, M. A., Zhou, H., Meigs, J. B., Lim, S., Blonde, L., MacDonald, E., Wang, R., LaVange, L. M., Pate, V., Buse, J. B. |
| المصدر: | Diabetes Care, 36(11) |
| سنة النشر: | 2013 |
| المجموعة: | Carolina Digital Repository (UNC - University of North Carolina) |
| مصطلحات موضوعية: | Tumeur maligne, Homme, Nutrition, Isophane insulin, Human, Endocrinology, Comparative study, Hipoglicemiante, Etude comparative, Treatment, Nutrición, Hypoglycemic agent, Malignant tumor, Incidence, Metabolic diseases, Hypoglycémiant, Insulin glargine, Hormone pancréatique, Insuline glargine, Maladie métabolique, Pancreatic hormone, Isophane insuline, Cancer, Traitement, Insuline à action lente, Endocrinologie |
| الوصف: | OBJECTIVETo add to the evidence on comparative long-term effects of insulin analog glargine versus human NPH insulin on the risk for cancer.RESEARCH DESIGN AND METHODSWe identified cohorts of initiators of glargine and human NPH without an insulin prescription during the prior 19 months among patients covered by the Inovalon Medical Outcomes Research for Effectiveness and Economics Registry (MORE2 Registry) between January 2003 and December 2010. Patients were required to have a second prescription of the same insulin within 180 days and to be free of cancer. We balanced cohorts on risk factors for cancer outcomes based on comorbidities, comedication, and health care use during the prior 12 months using inverse probability of treatment weighting. Incident cancer was defined as having two claims for cancer (any cancer) or the same cancer (breast, prostate, colon) within 2 months. We estimated adjusted hazard ratios (HRs) and their 95% CI using weighted Cox models censoring for stopping, switching, or augmenting insulin treatment, end of enrollment, and mortality.RESULTSMore patients initiated glargine (43,306) than NPH (9,147). Initiators of glargine (NPH) were followed for 1.2 (1.1) years and 50,548 (10,011) person-years; 993 (178) developed cancer. The overall HR was 1.12 (95% CI 0.95–1.32). Results were consistent for breast cancer, prostate cancer, and colon cancer; various durations of treatment; and sensitivity analyses.CONCLUSIONSPatients initiating insulin glargine rather than NPH do not seem to be at an increased risk for cancer. While our study contributes significantly to our evidence base for long-term effects, this evidence is very limited mainly based on actual dynamics in insulin prescribing. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.17615/7mzp-6k70Test; https://cdr.lib.unc.edu/downloads/tx31qr09s?file=thumbnailTest; https://cdr.lib.unc.edu/downloads/tx31qr09sTest |
| DOI: | 10.17615/7mzp-6k70 |
| الإتاحة: | https://doi.org/10.17615/7mzp-6k70Test https://cdr.lib.unc.edu/downloads/tx31qr09s?file=thumbnailTest https://cdr.lib.unc.edu/downloads/tx31qr09sTest |
| حقوق: | http://rightsstatements.org/vocab/InC/1.0Test/ |
| رقم الانضمام: | edsbas.DB59DF96 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17615/7mzp-6k70 |
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