التفاصيل البيبلوغرافية
| العنوان: |
POS0363 THE SIMPLE INDEX FOR SELF-ASSESSMENT OF DISEASE ACTIVITY IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS: A LONGITUDINAL COHORT VALIDATION |
| المؤلفون: |
Mok, C. C., Ho, L. Y., Chan, K. L., Meenakshi, J. |
| المصدر: |
Annals of the Rheumatic Diseases ; volume 81, issue Suppl 1, page 434.1-435 ; ISSN 0003-4967 1468-2060 |
| بيانات النشر: |
BMJ |
| سنة النشر: |
2022 |
| مصطلحات موضوعية: |
General Biochemistry, Genetics and Molecular Biology, Immunology, Immunology and Allergy, Rheumatology |
| الوصف: |
Background The SIMPLE (SIMple Disease Assessment for People with Lupus Erythematosus) index is a composite numeric tool that captures disease activity from patients’ self-assessment with minimal physicians’ input. The SIMPLE index consists of 2 components: patient self-reported survey questionnaire (3 items from the lupus symptoms domain from the validated LupusPRO, 10 items from Lupus Impact Tracker [LIT], change in the health status and current glucocorticoids use [and dose]) and two laboratory tests (low complements [C3/C4] and urine protein-creatinine ratio >0.5). The values are put in an equation to derive a number, which is transformed to a 0- to 100-point scale by a formula using weighted scores of the above parameters. The SIMPLE index has been validated in US with good correlation with physicians’ assessment of disease activity. Objectives To validate the SIMPLE index for systemic lupus erythematosus (SLE) disease activity assessment in a longitudinal cohort of Chinese patients. Methods Adult patients (age ≥18 years) who fulfilled the 2012 SLICC criteria for SLE and were followed in the Rheumatology clinics of Tuen Mun Hospital, Hong Kong were recruited. Patients were followed for a total of 3 consecutive visits, including hospitalization. Participants were invited to complete the SIMPLE questionnaire before seeing doctors on the same day of clinic visit or hospital stay. The two laboratory results were supplemented by research nurses. Physicians, who were blinded to the SIMPLE results, were asked to complete disease activity assessment by the SELENA-SLEDAI and physicians’ global assessment (PGA) after consultation. Correlation was made between the SIMPLE score and the SLEDAI/PGA scores by Spearman’s rank correlation test. Correlation was also performed for the changes in total/clinical SLEDAI, PGA with the change in SIMPLE index during subsequent visits relative to baseline. Results 399 SLE patients were studied (93.7% women; age 45.3±13.4 years; disease duration 13.3±8.0 years). The proportion of ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1136/annrheumdis-2022-eular.1476 |
| الإتاحة: |
https://doi.org/10.1136/annrheumdis-2022-eular.1476Test |
| رقم الانضمام: |
edsbas.DAE1F688 |
| قاعدة البيانات: |
BASE |
