دورية أكاديمية
The von Willebrand Factor stamps Plasmatic Extracellular Vesicles from Glioblastoma Patients
| العنوان: | The von Willebrand Factor stamps Plasmatic Extracellular Vesicles from Glioblastoma Patients |
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| المؤلفون: | Sabbagh, Quentin, André-Grégoire, Gwennan, Alves-Nicolau, Carolina, Dupont, Aurélien, Bidère, Nicolas, Jouglar, Emmanuel, Guével, Laëtitia, Frénel, Jean-Sébastien, Gavard, Julie |
| المساهمون: | Signaling in Oncogenesis, Angiogenesis and Permeability (CRCINA-ÉQUIPE 15), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), Institut de Cancérologie de l'Ouest Angers/Nantes (UNICANCER/ICO), UNICANCER, Biosit : biologie, santé, innovation technologique (SFR UMS CNRS 3480 - INSERM 018), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) |
| المصدر: | ISSN: 2045-2322. |
| بيانات النشر: | HAL CCSD Nature Publishing Group |
| سنة النشر: | 2021 |
| المجموعة: | Université de Rennes 1: Publications scientifiques (HAL) |
| مصطلحات موضوعية: | [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Glioblastoma is a devastating tumor of the central nervous system characterized by a poor survival and an extremely dark prognosis, making its diagnosis, treatment and monitoring highly challenging. Numerous studies have highlighted extracellular vesicles (EVs) as key players of tumor growth, invasiveness and resistance, as they carry and disseminate oncogenic material in the local tumor microenvironment and at distance. However, whether their quality and quantity reflect individual health status and changes in homeostasis is still not fully elucidated. Here, we separated EVs from plasma collected at different time points alongside with the clinical management of GBM patients. Our findings confirm that plasmatic EVs could be separated and characterized with standardized protocols, thereby ensuring the reliability of measuring vesiclemia, i.e . extracellular vesicle concentration in plasma. This unveils that vesiclemia is a dynamic parameter, which could be reflecting tumor burden and/or response to treatments. Further label-free liquid chromatography tandem mass spectrometry unmasks the von Willebrand Factor (VWF) as a selective protein hallmark for GBM-patient EVs. Our data thus support the notion that EVs from GBM patients showed differential protein cargos that can be further surveyed in circulating EVs, together with vesiclemia. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/34815502; inserm-03379903; https://www.hal.inserm.fr/inserm-03379903Test; https://www.hal.inserm.fr/inserm-03379903/documentTest; https://www.hal.inserm.fr/inserm-03379903/file/s41598-021-02254-7.pdfTest; BIORXIV: 2021.03.25.437073; PUBMED: 34815502 |
| DOI: | 10.1038/s41598-021-02254-7 |
| الإتاحة: | https://doi.org/10.1038/s41598-021-02254-7Test https://www.hal.inserm.fr/inserm-03379903Test https://www.hal.inserm.fr/inserm-03379903/documentTest https://www.hal.inserm.fr/inserm-03379903/file/s41598-021-02254-7.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.DAAA4165 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41598-021-02254-7 |
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