دورية أكاديمية
Maternal haemoglobin levels in pregnancy and child DNA methylation: A study in the pregnancy and childhood epigenetics consortium.
| العنوان: | Maternal haemoglobin levels in pregnancy and child DNA methylation: A study in the pregnancy and childhood epigenetics consortium. |
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| المؤلفون: | Ronkainen, J., Heiskala, A., Vehmeijer, F.O.L., Lowry, E., Caramaschi, D., Estrada Gutierrez, G., Heiss, J.A., Hummel, N., Keikkala, E., Kvist, T., Kupsco, A., Melton, P.E., Pesce, G., Soomro, M.H., Vives-Usano, M., Baïz, N., Binder, E., Czamara, D., Guxens, M., Mustaniemi, S., London, S.J., Rauschert, S., Vääräsmäki, M., Vrijheid, M., Ziegler, A.G., Annesi-Maesano, I., Bustamante, M., Huang, R.C., Hummel, S., Just, A.C., Kajantie, E., Lahti, J., Lawlor, D., Räikkönen, K., Järvelin, M.R., Felix, J.F., Sebert, S. |
| المصدر: | Epigenetics 17, 19-31 (2022) |
| بيانات النشر: | Taylor & Francis Inc |
| سنة النشر: | 2022 |
| المجموعة: | PuSH - Publikationsserver des Helmholtz Zentrums München |
| مصطلحات موضوعية: | Dna Methylation, Maternal Haemoglobin, Developmental Programming, Pregnancy |
| الوصف: | Altered maternal haemoglobin levels during pregnancy are associated with pre-clinical and clinical conditions affecting the fetus. Evidence from animal models suggests that these associations may be partially explained by differential DNA methylation in the newborn with possible long-term consequences. To test this in humans, we meta-analyzed the epigenome-wide associations of maternal haemoglobin levels during pregnancy with offspring DNA methylation in 3,967 newborn cord blood and 1,534 children and 1,962 adolescent whole-blood samples derived from 10 cohorts. DNA methylation was measured using Illumina Infinium Methylation 450K or MethylationEPIC arrays covering 450,000 and 850,000 methylation sites, respectively. There was no statistical support for the association of maternal haemoglobin levels with offspring DNA methylation either at individual methylation sites or clustered in regions. For most participants, maternal haemoglobin levels were within the normal range in the current study, whereas adverse perinatal outcomes often arise at the extremes. Thus, this study does not rule out the possibility that associations with offspring DNA methylation might be seen in studies with more extreme maternal haemoglobin levels. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1559-2294 1559-2308 |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/33331245; info:eu-repo/semantics/altIdentifier/wos/WOS:000606892400001; info:eu-repo/semantics/altIdentifier/isbn/1559-2294; info:eu-repo/semant; https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=60972Test; urn:isbn:1559-2294; urn:issn:1559-2294; urn:issn:1559-2308 |
| DOI: | 10.1080/15592294.2020.1864171 |
| الإتاحة: | https://doi.org/10.1080/15592294.2020.1864171Test https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=60972Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.DA730FF7 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 15592294 15592308 |
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| DOI: | 10.1080/15592294.2020.1864171 |