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Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease.

التفاصيل البيبلوغرافية
العنوان: Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease.
المؤلفون: Mattsson, Niklas, Groot, Colin, Jansen, Willemijn J, Landau, Susan M, Villemagne, Victor L, Engelborghs, Sebastiaan, Mintun, Mark M, Lleo, Alberto, Molinuevo, José Luis, Jagust, William J, Frisoni, Giovanni B, Ivanoiu, Adrian, Chételat, Gaël, Resende de Oliveira, Catarina, Rodrigue, Karen M, Kornhuber, Johannes, Wallin, Anders, Klimkowicz-Mrowiec, Aleksandra, Kandimalla, Ramesh, Popp, Julius, Aalten, Pauline P, Aarsland, Dag, Alcolea, Daniel, Almdahl, Ina S, Baldeiras, Inês, van Buchem, Mark A, Cavedo, Enrica, Chen, Kewei, Cohen, Ann D, Förster, Stefan, Fortea, Juan, Frederiksen, Kristian S, Freund-Levi, Yvonne, Gill, Kiran Dip, Gkatzima, Olymbia, Grimmer, Timo, Hampel, Harald, Herukka, Sanna-Kaisa, Johannsen, Peter, van Laere, Koen, de Leon, Mony J, Maier, Wolfgang, Marcusson, Jan, Meulenbroek, Olga, MøllergÃ¥rd, Hanne M, Morris, John C, Mroczko, Barbara, Nordlund, Arto, Prabhakar, Sudesh, Peters, Oliver, Rami, Lorena, Rodríguez-Rodríguez, Eloy, Roe, Catherine M, Rüther, Eckart, Santana, Isabel, Schröder, Johannes, Seo, Sang W, Soininen, Hilkka, Spiru, Luiza, Stomrud, Erik, Struyfs, Hanne, Teunissen, Charlotte E, Verhey, Frans R J, Vos, Stephanie J B, van Waalwijk van Doorn, Linda J C, Waldemar, Gunhild, Wallin, Ã…sa K, Wiltfang, Jens, Vandenberghe, Rik, Brooks, David J, Fladby, Tormod, Rowe, Christopher C, Drzezga, Alexander, Verbeek, Marcel M, Sarazin, Marie, Wolk, David A, Fleisher, Adam S, Klunk, William E, Na, Duk L, Sánchez-Juan, Pascual, Lee, Dong Young, Nordberg, Agneta, Tsolaki, Magda, Camus, Vincent, Rinne, Juha O, Fagan, Anne M, Zetterberg, Henrik, Blennow, Kaj, Rabinovici, Gil D, Hansson, Oskar, van Berckel, Bart N M, van der Flier, Wiesje M, Scheltens, Philip, Visser, Pieter Jelle, Ossenkoppele, Rik
المساهمون: UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service de neurologie
المصدر: Alzheimer's & Dementia, Vol. 14, no. 7, p. 913-924 (2018)
بيانات النشر: Elsevier Inc.
سنة النشر: 2018
المجموعة: DIAL@UCL (Université catholique de Louvain)
مصطلحات موضوعية: APOE, Age, Alzheimer's disease, Amyloid, CSF, Education, Geographical location, Mild cognitive impairment, PET, Prevalence, Sex, Subjective cognitive decline
الوصف: INTRODUCTION: Apolipoprotein E (APOE) ε4 is the major genetic risk factor for Alzheimer's disease (AD), but its prevalence is unclear because earlier studies did not require biomarker evidence of amyloid β (Aβ) pathology. METHODS: We included 3451 Aβ+ subjects (853 AD-type dementia, 1810 mild cognitive impairment, and 788 cognitively normal). Generalized estimating equation models were used to assess APOE ε4 prevalence in relation to age, sex, education, and geographical location. RESULTS: The APOE ε4 prevalence was 66% in AD-type dementia, 64% in mild cognitive impairment, and 51% in cognitively normal, and it decreased with advancing age in Aβ+ cognitively normal and Aβ+ mild cognitive impairment (P < .05) but not in Aβ+ AD dementia (P = .66). The prevalence was highest in Northern Europe but did not vary by sex or education. DISCUSSION: The APOE ε4 prevalence in AD was higher than that in previous studies, which did not require presence of Aβ pathology. Furthermore, our results highlight disease heterogeneity related to age and geographical location.
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 1552-5260
1552-5279
العلاقة: boreal:198864; http://hdl.handle.net/2078.1/198864Test; info:pmid/29601787; urn:ISSN:1552-5260; urn:EISSN:1552-5279
DOI: 10.1016/j.jalz.2018.02.009
الإتاحة: https://doi.org/10.1016/j.jalz.2018.02.009Test
http://hdl.handle.net/2078.1/198864Test
حقوق: info:eu-repo/semantics/restrictedAccess
رقم الانضمام: edsbas.DA64EE14
قاعدة البيانات: BASE
الوصف
تدمد:15525260
15525279
DOI:10.1016/j.jalz.2018.02.009