دورية أكاديمية
Diatom frustule silica extracted from Melosira nummuloides ameliorates acetaminophen-induced acute liver injury in mice
| العنوان: | Diatom frustule silica extracted from Melosira nummuloides ameliorates acetaminophen-induced acute liver injury in mice |
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| المؤلفون: | Choi, JH, Go, GM, Unno, T |
| المساهمون: | 114997, Choi, JH |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Acute liver injury (ALI), Diatom Frustule Silica (DFS), Hepatotoxicity, Melosira nummuloides, Pro-inflammatory cytokines |
| الوصف: | Melosira nummuloides is a type of diatom in the family Melosiraceae. Diatoms are unicellular microalgae widely distributed in aquatic environments. Diatoms are known to be suitable for many industrial and biomedical applications because of their high biocompatibility and ease of use. In this study, we investigated the hepatoprotective effect of diatom frustule silica (DFS) extracted from Melosira nummuloides on hepatotoxicant-induced liver injury. Hepatoprotective effects of DFS were examined using acetaminophen-induced acute liver injury (ALI) mouse model. We evaluated the hepatoprotective effects through hepatotoxicity, pro-inflammatory cytokines, transcriptional factors, upstream signaling pathways, and histopathological analysis by DFS in an animal model of acetaminophen-induced ALI. Our results showed serum alanine aminotransferase/aspartate aminotransferase activity and hepatic malondialdehyde formation were significantly attenuated upon DFS administration. DFS also ameliorated glutathione depletion and down-regulated acetaminophen-induced CYP2E1. DFS administration also down-regulated expressions of pro-inflammatory cytokines through preventing NF-κB activation by JNK1/2 phosphorylation inhibition. These findings demonstrate that the hepatoprotective effect of DFS is associated with suppression of inflammatory responses in an animal model of acetaminophen-induced ALI. © 2022, The Author(s). |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2468-0834 2468-0842 |
| العلاقة: | J024680834; http://repository.ajou.ac.kr/handle/201003/25261Test; https://applbiolchem.springeropen.com/articles/10.1186/s13765-022-00741-7Test; Applied biological chemistry, 65. : 73-73, 2022 |
| DOI: | 10.1186/s13765-022-00741-7 |
| الإتاحة: | https://doi.org/10.1186/s13765-022-00741-7Test http://repository.ajou.ac.kr/handle/201003/25261Test |
| رقم الانضمام: | edsbas.DA0BDDB8 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 24680834 24680842 |
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| DOI: | 10.1186/s13765-022-00741-7 |