دورية أكاديمية
Reduced level of synapsin I protein in the rat striatum after intraventricular administration of proteasome inhibitors: preliminary studies
| العنوان: | Reduced level of synapsin I protein in the rat striatum after intraventricular administration of proteasome inhibitors: preliminary studies |
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| المؤلفون: | Wójcik, S., Spodnik, J. H., Sidor-Kaczmarek, J., Moryś, J. |
| المساهمون: | This work was supported by a Polish Ministry of Science and Higher Education grant - NN401 005735 (to SW) and by a statutory (ST-11) grant from the Polish Ministry of Science and Higher Education ST-0011/07/211. |
| المصدر: | Folia Morphologica; Vol 74, No 4 (2015); 428-433 |
| بيانات النشر: | Via Medica |
| سنة النشر: | 2015 |
| المجموعة: | Via Medica Journals |
| مصطلحات موضوعية: | epoxomicin, lactacystin, MG-132, synapsin I, rat, neuronal nuclear antigen, Western blot |
| الوصف: | Background: We have recently described changes present in nigrostriatal terminals after intraperitoneal administration of MG-132 and changes that occur in the walls of the rat lateral ventricle after intraventricular administration of MG-132, lactacystin and epoxomicin — different classes of proteasome inhibitors. Substances that inhibit ubiquitin-proteasome system (UPS) activity, are intensively studied due to their potential role as novel therapeutic strategies in the treatment of cancer and ischaemia-reperfusion injury in the brain. The aim of this study is to determine the influence of intraventricular administration of MG-132, lactacystin and epoxomicin on the level in the rat striatum synapsin I — one of the most prominent neuron-specific phosphoproteins in the brain. Materials and methods and Results: Two weeks after administration of studied proteasome inhibitors, substantial reduction (up to 80%) of synapsin I was observed in the rat striatum. Because neurons, and especially dopaminergic ones, are sensitive to the depletion of proteasome function, we assume that observed synapsin I decrease may reflect changes in population of striatal neurons and/or nigrostriatal terminals. Conclusions: Understanding of cellular mechanisms standing behind our findings needs further studies, and could provide valuable contribution to the discussion on the mechanisms linking UPS inhibition and survival of neurons. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf; application/xhtml+xml |
| اللغة: | English |
| العلاقة: | https://journals.viamedica.pl/folia_morphologica/article/view/FM.2015.0103Test |
| DOI: | 10.5603/FM.2015.0103 |
| الإتاحة: | https://doi.org/10.5603/FM.2015.0103Test https://journals.viamedica.pl/folia_morphologica/article/view/FM.2015.0103Test |
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| رقم الانضمام: | edsbas.DA009096 |
| قاعدة البيانات: | BASE |
| DOI: | 10.5603/FM.2015.0103 |
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