التفاصيل البيبلوغرافية
| العنوان: |
Image_2_Assessing Histology Structures by Ex Vivo MR Microscopy and Exploring the Link Between MRM-Derived Radiomic Features and Histopathology in Ovarian Cancer.tiff |
| المؤلفون: |
Marion Tardieu (11966324), Yulia Lakhman (11966327), Lakhdar Khellaf (11966330), Maida Cardoso (5040383), Olivia Sgarbura (11966333), Pierre-Emmanuel Colombo (3422483), Mireia Crispin-Ortuzar (11966336), Evis Sala (3485), Christophe Goze-Bac (845088), Stephanie Nougaret (11966339) |
| سنة النشر: |
2022 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Cancer, Cancer Cell Biology, Cancer Diagnosis, Cancer Genetics, Cancer Therapy (excl. Chemotherapy and Radiation Therapy), Chemotherapy, Haematological Tumours, Molecular Targets, Radiation Therapy, Solid Tumours, Oncology and Carcinogenesis not elsewhere classified, ovarian cancer, MRI, radiomics, machine learning, histology |
| الوصف: |
The value of MR radiomic features at a microscopic scale has not been explored in ovarian cancer. The objective of this study was to probe the associations of MR microscopy (MRM) images and MRM-derived radiomic maps with histopathology in high-grade serous ovarian cancer (HGSOC). Nine peritoneal implants from 9 patients with HGSOC were imaged ex vivo with MRM using a 9.4-T MR scanner. All MRM images and computed pixel-wise radiomics maps were correlated with the slice-matched stroma and tumor proportion maps derived from whole histopathologic slide images (WHSI) of corresponding peritoneal implants. Automated MRM-derived segmentation maps of tumor and stroma were constructed using holdout test data and validated against the histopathologic gold standard. Excellent correlation between MRM images and WHSI was observed (Dice index = 0.77). Entropy, correlation, difference entropy, and sum entropy radiomic features were positively associated with high stromal proportion (r = 0.97,0.88, 0.81, and 0.96 respectively, p < 0.05). MR signal intensity, energy, homogeneity, auto correlation, difference variance, and sum average were negatively associated with low stromal proportion (r = –0.91, –0.93, –0.94, –0.9, –0.89, –0.89, respectively, p < 0.05). Using the automated model, MRM predicted stromal proportion with an accuracy ranging from 61.4% to 71.9%. In this hypothesis-generating study, we showed that it is feasible to resolve histologic structures in HGSOC using ex vivo MRM at 9.4 T and radiomics. |
| نوع الوثيقة: |
still image |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/figure/Image_2_Assessing_Histology_Structures_by_Ex_Vivo_MR_Microscopy_and_Exploring_the_Link_Between_MRM-Derived_Radiomic_Features_and_Histopathology_in_Ovarian_Cancer_tiff/18665882Test |
| DOI: |
10.3389/fonc.2021.771848.s002 |
| الإتاحة: |
https://doi.org/10.3389/fonc.2021.771848.s002Test |
| حقوق: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.D9FC9032 |
| قاعدة البيانات: |
BASE |
