دورية أكاديمية
The role of aging and brain-derived neurotrophic factor signaling in expression of base excision repair genes in the human brain ; ENEngelskEnglishThe role of aging and brain-derived neurotrophic factor signaling in expression of base excision repair genes in the human brain
| العنوان: | The role of aging and brain-derived neurotrophic factor signaling in expression of base excision repair genes in the human brain ; ENEngelskEnglishThe role of aging and brain-derived neurotrophic factor signaling in expression of base excision repair genes in the human brain |
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| المؤلفون: | Hindkjær Lautrup, Sofie, Myrup Holst, Camilla, Yde, Anne, Asmussen, Stine, Thinggaard, Vibeke, Larsen, Knud, Laursen, Lisbeth Schmidt, Richner, Mette, Vægter, Christian B., Prieto, G. Aleph, Berchtold, Nicole, Cotman, Carl W., Stevnsner, Tinna |
| المصدر: | 1474-9718. |
| سنة النشر: | 2023 |
| المجموعة: | Universitet i Oslo: Digitale utgivelser ved UiO (DUO) |
| الوصف: | DNA damage is a central contributor to the aging process. In the brain, a major threat to the DNA is the considerable amount of reactive oxygen species produced, which can inflict oxidative DNA damage. This type of damage is removed by the base excision repair (BER) pathway, an essential DNA repair mechanism, which contributes to genome stability in the brain. Despite the crucial role of the BER pathway, insights into how this pathway is affected by aging in the human brain and the underlying regulatory mechanisms are very limited. By microarray analysis of four cortical brain regions from humans aged 20–99 years ( n = 57), we show that the expression of core BER genes is largely downregulated during aging across brain regions. Moreover, we find that expression of many BER genes correlates positively with the expression of the neurotrophin brain‐derived neurotrophic factor (BDNF) in the human brain. In line with this, we identify binding sites for the BDNF‐activated transcription factor, cyclic‐AMP response element‐binding protein (CREB), in the promoter of most BER genes and confirm the ability of BDNF to regulate several BER genes by BDNF treatment of mouse primary hippocampal neurons. Together, these findings uncover the transcriptional landscape of BER genes during aging of the brain and suggest BDNF as an important regulator of BER in the human brain. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | Hindkjær Lautrup, Sofie Myrup Holst, Camilla Yde, Anne Asmussen, Stine Thinggaard, Vibeke Larsen, Knud Laursen, Lisbeth Schmidt Richner, Mette Vægter, Christian B. Prieto, G. Aleph Berchtold, Nicole Cotman, Carl W. Stevnsner, Tinna . The role of aging and brain-derived neurotrophic factor signaling in expression of base excision repair genes in the human brain. Aging Cell. 2023, 22(9); http://hdl.handle.net/10852/106914Test; 2159702; info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Aging Cell&rft.volume=22&rft.spage=&rft.date=2023; Aging Cell; 22; 20; https://doi.org/10.1111/acel.13905Test |
| DOI: | 10.1111/acel.13905 |
| الإتاحة: | https://doi.org/10.1111/acel.13905Test http://hdl.handle.net/10852/106914Test |
| حقوق: | Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.D99BACA0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/acel.13905 |
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