دورية أكاديمية
Imaging of cardiac fibroblast activation in a patient after acute myocardial infarction using 68Ga-FAPI-04
| العنوان: | Imaging of cardiac fibroblast activation in a patient after acute myocardial infarction using 68Ga-FAPI-04 |
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| المؤلفون: | Notohamiprodjo, Susan, Nekolla, Stephan G., Robu, Stephanie, Villagran Asiares, Alberto, Kupatt, Christian, Ibrahim, Tareq, Laugwitz, Karl-Ludwig, Makowski, Marcus, schwaiger, markus, Weber, Wolfgang, Varasteh, Zohreh |
| المصدر: | http://lobid.org/resources/99370679142406441Test#!, 29(5):2254-2261. |
| سنة النشر: | 2021 |
| المجموعة: | Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| مصطلحات موضوعية: | diagnostic and prognostic application, molecular imaging agents, Fibroblasts/pathology [MeSH], Myocardial Infarction/pathology [MeSH], Positron Emission Tomography Computed Tomography [MeSH], Rats [MeSH], hybrid imaging, Case Presentation Corner, Animals [MeSH], PET, Gallium Radioisotopes [MeSH], Membrane Proteins/metabolism [MeSH], Myocardial Infarction/diagnostic imaging [MeSH], Quinolines [MeSH], CAD, myocardial ischemia and infarction, Fibroblasts/metabolism [MeSH] |
| الوصف: | Our previous study has demonstrated the feasibility of noninvasive imaging of fibroblast activation protein (FAP)-expression after myocardial infarction (MI) in MI-territory in a rat model with 68 Ga-FAPI-04-PET. In the current extended clinical case, we sought to delineate cardiac uptake of 68 Ga-FAPI-04 in a patient after MI with clinical indication for the evidence of fibroblast activation. Carcinoma patients without cardiac disease underwent 68 Ga-FAPI-04-PET/CT as control. The patient with one-vessel disease underwent dynamic 68 Ga-FAPI-04-cardiac-PET/CMR for 60 minutes. Correlation of cardiac 68 Ga-FAPI-04 uptake with clinical findings, ECG, echocardiography, coronary-arteriography and enhanced cardiac-MRI with T1 MOLLI and ECV mapping were performed. No uptake was found in normal myocardium and in mature scar. A focal intense 68 Ga-FAPI-04 uptake with continuous wash-out in the infarct territory of coronary occlusion correlating with T1 and ECV mapping was observed. The uptake of 68 Ga-FAPI-04 extends beyond the actual infarcted area and overestimates the infarct size as confirmed by follow-up CMR. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://repository.publisso.de/resource/frl:6445576Test; https://doi.org/10.1007/s12350-021-02603-zTest; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553764Test/ |
| DOI: | 10.1007/s12350-021-02603-z |
| الإتاحة: | https://doi.org/10.1007/s12350-021-02603-zTest https://repository.publisso.de/resource/frl:6445576Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553764Test/ |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.D976420A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s12350-021-02603-z |
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