دورية أكاديمية
Interleukin-26 activates macrophages and facilitates killing of Mycobacterium tuberculosis
| العنوان: | Interleukin-26 activates macrophages and facilitates killing of Mycobacterium tuberculosis |
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| المؤلفون: | Hawerkamp, Heike C., van Geelen, Lasse, Korte, Jan, Di Domizio, Jeremy, Swidergall, Marc, Momin, Afaque Ahmad Imtiyaz, Guzmán-Vega, Francisco J., Arold, Stefan T., Ernst, Joachim, Gilliet, Michel, Kalscheuer, Rainer, Homey, Bernhard, Meller, Stephan |
| المساهمون: | Biological and Environmental Sciences and Engineering (BESE) Division, Bioscience Program, Computational Bioscience Research Center (CBRC), Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division, Structural Biology and Engineering, Department of Dermatology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany., Department of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University, Düsseldorf, Germany., Department of Dermatology, University Hospital CHUV, Lausanne, Switzerland., Department of Biology, Molecular Mycology, Heinrich-Heine-University, Düsseldorf, Germany. |
| بيانات النشر: | Springer Nature |
| سنة النشر: | 2020 |
| المجموعة: | King Abdullah University of Science and Technology: KAUST Repository |
| الوصف: | Tuberculosis-causing Mycobacterium tuberculosis (Mtb) is transmitted via airborne droplets followed by a primary infection of macrophages and dendritic cells. During the activation of host defence mechanisms also neutrophils and T helper 1 (TH1) and TH17 cells are recruited to the site of infection. The TH17 cell-derived interleukin (IL)-17 in turn induces the cathelicidin LL37 which shows direct antimycobacterial effects. Here, we investigated the role of IL-26, a TH1- and TH17-associated cytokine that exhibits antimicrobial activity. We found that both IL-26 mRNA and protein are strongly increased in tuberculous lymph nodes. Furthermore, IL-26 is able to directly kill Mtb and decrease the infection rate in macrophages. Binding of IL-26 to lipoarabinomannan might be one important mechanism in extracellular killing of Mtb. Macrophages and dendritic cells respond to IL-26 with secretion of tumor necrosis factor (TNF)-α and chemokines such as CCL20, CXCL2 and CXCL8. In dendritic cells but not in macrophages cytokine induction by IL-26 is partly mediated via Toll like receptor (TLR) 2. Taken together, IL-26 strengthens the defense against Mtb in two ways: firstly, directly due to its antimycobacterial properties and secondly indirectly by activating innate immune mechanisms. ; We thank S. Köhler from the Center for Advanced Imaging, Heinrich-Heine-University Düsseldorf for performing SEM. We further thank H. Mayringer, N. Simiantonaki and I. Esposito from the Institute of Pathology, Medical Faculty, Heinrich-Heine-University Düsseldorf for providing FFPE-lymph node sections from healthy individuals and tuberculosis patients. S. Meller was supported by the Stettendorf Stiftung. ; Open Access funding enabled and organized by Projekt DEAL. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| تدمد: | 2045-2322 |
| العلاقة: | http://www.nature.com/articles/s41598-020-73989-yTest; Hawerkamp, H. C., van Geelen, L., Korte, J., Di Domizio, J., Swidergall, M., Momin, A. A., … Meller, S. (2020). Interleukin-26 activates macrophages and facilitates killing of Mycobacterium tuberculosis. Scientific Reports, 10(1). doi:10.1038/s41598-020-73989-y; Scientific Reports; http://hdl.handle.net/10754/665596Test; 10 |
| DOI: | 10.1038/s41598-020-73989-y |
| الإتاحة: | https://doi.org/10.1038/s41598-020-73989-yTest http://hdl.handle.net/10754/665596Test |
| حقوق: | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.D8E0E086 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-020-73989-y |