دورية أكاديمية
Soluble interleukin-6 receptor regulates interleukin-6-dependent vascular remodeling in long-distance runners
| العنوان: | Soluble interleukin-6 receptor regulates interleukin-6-dependent vascular remodeling in long-distance runners |
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| المؤلفون: | Villar Fincheira, Paulina Fernanda, Paredes, Aaron J., Hernández Díaz, Tomás Alonso, Norambuena Soto, Ignacio Esteban, Cancino Arenas, Nicole Ester, Sanhueza Olivares, Fernanda, Contreras Briceño, Felipe, Mandiola, Jorge, Bruneau Leyton, Nicole Nayira, García Nannig, Lorena, Ocaranza, María Paz, Troncoso Cotal, Rodrigo Hernán, Gabrielli, Luigi, Chiong Lay, Mario Martin |
| المصدر: | Frontiers in Physiology |
| بيانات النشر: | Frontiers Media |
| سنة النشر: | 2021 |
| المجموعة: | Universidad de Chile: Repositorio académico |
| مصطلحات موضوعية: | Interleukin-6, Soluble interleukin-6 receptor, Vascular smooth muscle cell, Runners, Exercise |
| الوصف: | Little is known about the effects of training load on exercise-induced plasma increase of interleukin-6 (IL-6) and soluble IL-6 receptor (sIL-6R) and their relationship with vascular remodeling. We sought to evaluate the role of sIL 6R as a regulator of IL-6-induced vascular remodeling. Forty-four male marathon runners were recruited and allocated into two groups: low-training (LT, <100 km/week) and high-training (HT, >= 100 km/week), 22 athletes per group. Twenty-one sedentary participants were used as reference. IL-6, sIL-6R and sgp130 levels were measured in plasma samples obtained before and immediately after finishing a marathon (42.2-km). Aortic diameter was measured by echocardiography. The inhibitory effect of sIL-6R on IL-6-induced VSMC migration was assessed using cultured A7r5 VSMCs. Basal plasma IL-6 and sIL-6R levels were similar among sedentary and athlete groups. Plasma IL-6 and sIL-6R levels were elevated after the marathon, and HT athletes had higher post-race plasma sIL-6R, but not IL-6, level than LT athletes. No changes in sgp130 plasma levels were found in LT and HT groups before and after running the marathon. Athletes had a more dilated ascending aorta and aortic root than sedentary participants with no differences between HT and LT athletes. However, a positive correlation between ascending aorta diameter and plasma IL-6 levels corrected by training load and years of training was observed. IL-6 could be responsible for aorta dilation because IL-6 stimulated VSMC migration in vitro, an effect that is inhibited by sIL-6R. However, IL-6 did not modify cell proliferation, collagen type I and contractile protein of VSMC. Our results suggest that exercise induces vascular remodeling. A possible association with IL-6 is proposed. Because sIL-6R inhibits IL-6-induced VSMC migration, a possible mechanism to regulate IL-6-dependent VSMC migration is also proposed. ; Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) CONICYT FONDECYT 1170963 Comision Nacional de ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | Frontiers in Physiology October 2021 Volume 12 Article 722528; https://repositorio.uchile.cl/handle/2250/185657Test |
| DOI: | 10.3389/fphys.2021.722528 |
| الإتاحة: | https://doi.org/10.3389/fphys.2021.722528Test https://repositorio.uchile.cl/handle/2250/185657Test |
| حقوق: | Attribution-NonCommercial-NoDerivs 3.0 United States ; http://creativecommons.org/licenses/by-nc-nd/3.0/usTest/ |
| رقم الانضمام: | edsbas.D8B95747 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fphys.2021.722528 |
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