دورية أكاديمية
SMBA1, a Bax Activator, Induces Cell Cycle Arrest and Apoptosis in Malignant Glioma Cells
| العنوان: | SMBA1, a Bax Activator, Induces Cell Cycle Arrest and Apoptosis in Malignant Glioma Cells |
|---|---|
| المؤلفون: | Fan, Shuangbo, Xu, Qian, Wang, Liang, Wan, Yulin, Qiu, Sheng |
| المصدر: | Pharmacology ; volume 105, issue 3-4, page 164-172 ; ISSN 0031-7012 1423-0313 |
| بيانات النشر: | S. Karger AG |
| سنة النشر: | 2019 |
| الوصف: | SMBA1 (small-molecule Bax agonists 1), a small molecular activator of Bax, is a potential anti-tumour agent. In the present study, we investigated the biological effects of SMBA1 on glioblastoma (GBM) cells. SMBA1 reduced the viabilities of U87MG, U251 and T98G cells in a time- and dose-dependent manner. Moreover, treatment with SMBA1 induced cell cycle arrest at the G2/M phase transition, accompanied by the downregulation of Cdc25c and cyclin B1 and the upregulation of p21. SMBA1 also induced apoptosis of GBM cells in a dose-dependent manner. Mechanistically, SMBA1 induced apoptosis via the intrinsic pathway. Silencing of Bax or ectopic expression of Bcl-2 significantly inhibited SMBA1-induced apoptosis. Moreover, SMBA1 inhibited the growth of U87MG xenograft tumours in vivo. Overall, SMBA1 shows anti-proliferative effects against GBM cells through activation of the intrinsic apoptosis pathway. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1159/000500292 |
| الإتاحة: | https://doi.org/10.1159/000500292Test https://www.karger.com/Article/Pdf/500292Test |
| حقوق: | https://www.karger.com/Services/SiteLicensesTest ; https://www.karger.com/Services/SiteLicensesTest |
| رقم الانضمام: | edsbas.D8AE6D5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1159/000500292 |
|---|