التفاصيل البيبلوغرافية
| العنوان: |
S2 Data - |
| المؤلفون: |
Ievgeniia Ostrov, Yongjia Gong, Joshua B. Zuk, Purni C. K. Wickramasinghe, Irina Tmenova, Diana E. Roopchand, Liping Zhao, Ilya Raskin |
| سنة النشر: |
2024 |
| مصطلحات موضوعية: |
Microbiology, Molecular Biology, Physiology, Biotechnology, Evolutionary Biology, Ecology, Inorganic Chemistry, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, shannon index diversity, associated — conditions, three healthy donors, iron oxidation patterns, div >< p, gut bacteria responding, gut dysbiosis induced, elemental iron reversed, elemental iron, induced dysbiosis, tested donors, iron treatments, iron treatment, induced disruption, gut microbiota, shigella <, ruminococcaceae <, ros state, results suggested, partially reversed |
| الوصف: |
Gut dysbiosis induced by oxygen and reactive oxygen species may be related to the development of inflammation, resulting in metabolic syndrome and associated—conditions in the gut. Here we show that elemental iron can serve as an antioxidant and reverse the oxygen-induced dysbiosis. Fecal samples from three healthy donors were fermented with elemental iron and/or oxygen. 16S rRNA analysis revealed that elemental iron reversed the oxygen-induced disruption of Shannon index diversity of the gut microbiota.The bacteria lacking enzymatic antioxidant systems also increased after iron treatment. Inter-individual differences, which corresponded to iron oxidation patterns, were observed for the tested donors. Gut bacteria responding to oxygen and iron treatments were identified as guilds, among which, Escherichia-Shigella was promoted by oxygen and depressed by elemental iron, while changes in bacteria such as Bifidobacterium , Blautia , Eubacterium , Ruminococcaceae , Flavonifractor , Oscillibacter , and Lachnospiraceae were reversed by elemental iron after oxygen treatment. Short-chain fatty acid production was inhibited by oxygen and this effect was partially reversed by elemental iron. These results suggested that elemental iron can regulate the oxygen/ROS state and protect the gut microbiota from oxidative stress. |
| نوع الوثيقة: |
dataset |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/dataset/S2_Data_-/25299975Test |
| DOI: |
10.1371/journal.pone.0298592.s004 |
| الإتاحة: |
https://doi.org/10.1371/journal.pone.0298592.s004Test
https://figshare.com/articles/dataset/S2_Data_-/25299975Test |
| حقوق: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.D7D75B77 |
| قاعدة البيانات: |
BASE |
