دورية أكاديمية
Extracellular vesicles are carriers of adiponectin with insulin-sensitizing and anti-inflammatory properties
| العنوان: | Extracellular vesicles are carriers of adiponectin with insulin-sensitizing and anti-inflammatory properties |
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| المؤلفون: | Blandin, Alexia, Amosse, Jérémy, Froger, Josy, Hilairet, Gregory, Durcin, Maëva, Fizanne, Lionel, Ghesquière, Valentine, Prieur, Xavier, Chaigneau, Julien, Vergori, Luisa, Dray, Cédric, Pradère, Jean-Philippe, Blandin, Stéphanie, Dupont, Joëlle, Ducluzeau, Pierre-Henri, Dubois, Sèverine, Boursier, Jérôme, Cariou, Bertrand, Le Lay, Soazig |
| المساهمون: | Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique EHESP (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique EHESP (EHESP), SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques (ICAT), Université d'Angers (UA), ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX-lab), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques (HIFIH), Interactions Biotiques et Santé Végétale (IBSV), Institut National de la Recherche Agronomique (INRA)-Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Centre National de la Recherche Scientifique (CNRS), Physiologie de la reproduction et des comportements Nouzilly (PRC), Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), ANR-22-CE18-0026,EVADIPO,Les vésicules extracellulaires enrichies en adiponectine : une thérapie anti-diabétique innnovante(2022) |
| المصدر: | ISSN: 2211-1247. |
| بيانات النشر: | HAL CCSD Elsevier Inc |
| سنة النشر: | 2023 |
| المجموعة: | Université François-Rabelais de Tours: HAL |
| مصطلحات موضوعية: | CP: Metabolism, EVs, adipokines, adiponectin, adipose tissue, exosomes, extracellular vesicles, inflammtion, insulin resitance, obesity, type 2 diabetes, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Recent evidence supporting that adipose tissue (AT)-derived extracellular vesicles (EVs) carry an important part of the AT secretome led us to characterize the EV-adipokine profile. In addition to evidencing a high AT-derived EV secretion ability that is further increased by obesity, we identify enrichment of oligomeric forms of adiponectin in small EVs (sEVs). This adipokine is mainly distributed at the EV external surface as a result of nonspecific adsorption of soluble adiponectin. EVs also constitute stable conveyors of adiponectin in the blood circulation. Adiponectin-enriched sEVs display in vitro insulin-sensitizing effects by binding to regular adiponectin receptors. Adoptive transfer of adiponectin-enriched sEVs in high-fat-diet-fed mice prevents animals from gaining weight and ameliorated insulin resistance and tissue inflammation, with major effects observed in the AT and liver. Our results therefore provide information regarding adiponectin-related metabolic responses by highlighting EVs as delivery platforms of metabolically active forms of adiponectin molecules. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/37605533; hal-04198014; https://hal.science/hal-04198014Test; https://hal.science/hal-04198014/documentTest; https://hal.science/hal-04198014/file/PIIS221112472300877X.pdfTest; PUBMED: 37605533; WOS: 001061777000001 |
| DOI: | 10.1016/j.celrep.2023.112866 |
| الإتاحة: | https://doi.org/10.1016/j.celrep.2023.112866Test https://hal.science/hal-04198014Test https://hal.science/hal-04198014/documentTest https://hal.science/hal-04198014/file/PIIS221112472300877X.pdfTest |
| حقوق: | http://creativecommons.org/licenses/by-nc-ndTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.D721237D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.celrep.2023.112866 |
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