التفاصيل البيبلوغرافية
| العنوان: |
Mild preischemia hypothermia adversely affects postischemic myocardial function in the neonatal piglet heart |
| المؤلفون: |
Keller, V. Antoine, Melancon, J. Keith, Thomas, Thomas V., Pigott, John D., Flint, Lewis M., Lefer, David J., Ferrara, John J. |
| المصدر: |
Surgery Faculty Publications |
| بيانات النشر: |
Health Sciences Research Commons |
| سنة النشر: |
1997 |
| المجموعة: |
George Washington University: Health Sciences Research Commons (HSRC) |
| مصطلحات موضوعية: |
Hypothermia, Ischemia-reperfusion, Neonatal cardiac function |
| الوصف: |
Background: During cardiac surgery, operative hypothermia has been shown to be beneficial in certain situations, although in children perioperative hypothermia has been associated with several physiologic alterations that have proven detrimental to their postoperative function. Little attention has been given to the effects of mild (34.5°C) perioperative hypothermia on postischemic myocardial function in the pediatric population. It was hypothesized that mild hypothermia would be detrimental to postischemic ventricular function in the neonatal heart. Methods: Neonatal (0-2 days old) piglets were subjected to mild perioperative hypothermia without rewarming (HT-only, n = 6), hypothermia followed by rewarming (HT-RW, n = 6), or continuous normothermia (NT, n = 8). The hearts were rapidly excised, suspended on an isolated perfusion apparatus, and allowed to spontaneously beat while being perfused with an asanguinous solution. All hearts were subjected to 20 min global, normothermic, zero-flow ischemia followed by 45 min oxygenated crystallite buffer reperfusion (I-R). Results: Compared to that of NT piglets, there were significant (P < 0.05) reductions in recovery of left ventricular (LV) diastolic and systolic function following ischemia and reperfusion in HT-RW animals. When the hearts were rendered ischemic without first rewarming, the degree of myocardial dysfunction was not as severe. In contrast to the NT piglets, HT-RW animals demonstrated significant (P < 0.05) reductions in the final recovery of LV developed pressure (71 ± 6 vs 105 ± 6 in NT), LV rate pressure product (52 ± 4 vs 102 ± 9 NT), and LV end diastolic pressure (32 ± 7 vs 3 ± 1 in NT) following I-R. When compared to the HT-RW group, HT-only piglets did not exhibit significant differences in systolic function, although diastolic function was minimally altered initially as evidenced by the slight elevation of LV end diastolic pressure at 5 min, with reperfusion in the HT-only group (P < 0.05). Conclusions: In this newborn piglet model, ... |
| نوع الوثيقة: |
text |
| اللغة: |
unknown |
| العلاقة: |
https://hsrc.himmelfarb.gwu.edu/smhs_surgery_facpubs/3133Test |
| الإتاحة: |
https://hsrc.himmelfarb.gwu.edu/smhs_surgery_facpubs/3133Test |
| رقم الانضمام: |
edsbas.D709C831 |
| قاعدة البيانات: |
BASE |
