دورية أكاديمية
The Role of Glial Cells in Different Phases of Migraine: Lessons from Preclinical Studies
| العنوان: | The Role of Glial Cells in Different Phases of Migraine: Lessons from Preclinical Studies |
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| المؤلفون: | Gliga, Otilia, vila-pueyo, marta, Gallardo López, Víctor J., Pozo-Rosich, Patricia |
| المساهمون: | Institut Català de la Salut, Vila-Pueyo M, Gliga O, Gallardo VJ Grup de Recerca de Cefalea i Dolor Neurològic, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Pozo-Rosich P Grup de Recerca de Cefalea i Dolor Neurològic, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Unitat de Cefalees, Servei de Neurologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus |
| المصدر: | Scientia |
| بيانات النشر: | MDPI |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Migranya, Astròcits, Neuròglia, DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Headache Disorders::Headache Disorders, Primary::Migraine Disorders, ANATOMY::Cells::Neuroglia::Astrocytes, ANATOMY::Cells::Neuroglia, ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos con cefaleas::cefaleas primarias::trastornos migrañosos, ANATOMÍA::células::neuroglía::astrocitos, ANATOMÍA::células::neuroglía |
| الوصف: | Chronic Migraine; Headache; Microglia ; Migranya crònica; Mal de cap; Micròglia ; Migraña crónica; Dolor de cabeza; Microglía ; Migraine is a complex and debilitating neurological disease that affects 15% of the population worldwide. It is defined by the presence of recurrent severe attacks of disabling headache accompanied by other debilitating neurological symptoms. Important advancements have linked the trigeminovascular system and the neuropeptide calcitonin gene-related peptide to migraine pathophysiology, but the mechanisms underlying its pathogenesis and chronification remain unknown. Glial cells are essential for the correct development and functioning of the nervous system and, due to its implication in neurological diseases, have been hypothesised to have a role in migraine. Here we provide a narrative review of the role of glia in different phases of migraine through the analysis of preclinical studies. Current evidence shows that astrocytes and microglia are involved in the initiation and propagation of cortical spreading depolarization, the neurophysiological correlate of migraine aura. Furthermore, satellite glial cells within the trigeminal ganglia are implicated in the initiation and maintenance of orofacial pain, suggesting a role in the headache phase of migraine. Moreover, microglia in the trigeminocervical complex are involved in central sensitization, suggesting a role in chronic migraine. Taken altogether, glial cells have emerged as key players in migraine pathogenesis and chronification and future therapeutic strategies could be focused on targeting them to reduce the burden of migraine. ; The APC of this article was partly covered by a grant from the Japanese Headache Society. M.V.-P. was supported by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie IF grant agreement No. 101023175. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1422-0067 |
| العلاقة: | International Journal of Molecular Sciences;24(16); https://doi.org/10.3390/ijms241612553Test; info:eu-repo/grantAgreement/EC/H2020/101023175; Vila-Pueyo M, Gliga O, Gallardo VJ, Pozo-Rosich P. The Role of Glial Cells in Different Phases of Migraine: Lessons from Preclinical Studies. Int J Mol Sci. 2023 Aug 8;24(16):12553.; https://hdl.handle.net/11351/10268Test |
| DOI: | 10.3390/ijms241612553 |
| الإتاحة: | https://doi.org/10.3390/ijms241612553Test https://hdl.handle.net/11351/10268Test |
| حقوق: | Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0Test/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.D6D52C83 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14220067 |
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| DOI: | 10.3390/ijms241612553 |