دورية أكاديمية
Assessment of the potential value of plasma Torque Teno virus DNA load monitoring to predict cytomegalovirus DNAemia in patients with hematological malignancies treated with small molecule inhibitors: A proof-of-concept study
| العنوان: | Assessment of the potential value of plasma Torque Teno virus DNA load monitoring to predict cytomegalovirus DNAemia in patients with hematological malignancies treated with small molecule inhibitors: A proof-of-concept study |
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| المؤلفون: | Solano de la Asunción, Carlos, Giménez, Estela, Hernandez-Boluda, Juan Carlos, Terol, M. Jose, Albert, Eliseo, López-Jiménez, Javier, Fox, Maria Laura |
| المساهمون: | Institut Català de la Salut, Solano de la Asunción C, Albert E Microbiology Service, INCLIVA Research Institute, Hospital Clínico Universitario, Valencia, Spain. Giménez E Microbiology Service, INCLIVA Research Institute, Hospital Clínico Universitario, Valencia, Spain. Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain. Hernández-Boluda JC Hematology Service, INCLIVA Research Institute, Hospital Clínico Universitario, Valencia, Spain. Terol MJ Hematology Service, INCLIVA Research Institute, Hospital Clínico Universitario, Valencia, Spain. Department of Medicine, School of Medicine, University of Valencia, Valencia, Spain. López J Hematology Service, Hospital Universitario Ramón y Cajal, Madrid, Spain. Fox ML Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Servei d’Hematologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus |
| المصدر: | Scientia |
| بيانات النشر: | Wiley |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Infeccions per citomegalovirus, Sang - Càncer, ADN, DISEASES::Neoplasms::Neoplasms by Site::Hematologic Neoplasms, DISEASES::Virus Diseases::DNA Virus Infections::Herpesviridae Infections::Cytomegalovirus Infections, CHEMICALS AND DRUGS::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::DNA::DNA, Viral, ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias hematológicas, ENFERMEDADES::virosis::infecciones por virus ADN::infecciones por Herpesviridae::infecciones por Citomegalovirus, COMPUESTOS QUÍMICOS Y DROGAS::nucleótidos y nucleósidos de ácidos nucleicos::ácidos nucleicos::ADN::ADN vírico |
| الوصف: | T-cells; Ibrutinib; DNA load ; Células T; Ibrutinib; Carga de ADN ; Cèl·lules T; Ibrutinib; Càrrega d'ADN ; It is unknown whether Torque Teno virus (TTV) DNA load monitoring could anticipate the development of infectious events in hematological patients undergoing treatment with small molecular targeting agents. We characterized the kinetics of plasma TTV DNA in patients treated with ibrutinib or ruxolitinib and assessed whether TTV DNA load monitoring could predict the occurrence of Cytomegalovirus (CMV) DNAemia or the magnitude of CMV-specific T-cell responses. Multicenter, retrospective, observational study, recruiting 20 patients treated with ibrutinib and 21 with ruxolitinib. Plasma TTV and CMV DNA loads were quantified by real-time PCR at baseline and days +15, +30, +45, +60, +75, +90, +120, +150, and +180 after treatment inception. Enumeration of CMV-specific interferon-γ (IFN-γ)-producing CD8+ and CD4+ T-cells in whole blood was performed by flow cytometry. Median TTV DNA load in ibrutinib-treated patients increased significantly (p = 0.025) from baseline (median: 5.76 log10 copies/mL) to day +120 (median: 7.83 log10 copies/mL). A moderate inverse correlation (Rho = −0.46; p < 0.001) was found between TTV DNA load and absolute lymphocyte count. In ruxolitinib-treated patients, TTV DNA load quantified at baseline was not significantly different from that measured after treatment inception (p ≥ 0.12). TTV DNA load was not predictive of the subsequent occurrence of CMV DNAemia in either patient group. No correlation was observed between TTV DNA loads and CMV-specific IFN-γ-producing CD8+ and CD4+ T-cell counts in either patient group. The data did not support the hypothesis that TTV DNA load monitoring in hematological patients treated with ibrutinib or ruxolitinib could be useful to predict either the occurrence of CMV DNAemia or the level of CMV-specific T-cell reconstitution; nevertheless, due to the small sample size, further studies involving larger cohorts are warranted to elucidate this issue. ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0146-6615 |
| العلاقة: | Journal of Medical Virology;95(7); https://doi.org/10.1002/jmv.28933Test; Solano de la Asunción C, Giménez E, Hernández-Boluda JC, Terol MJ, Albert E, López J, et al. Assessment of the potential value of plasma Torque Teno virus DNA load monitoring to predict cytomegalovirus DNAemia in patients with hematological malignancies treated with small molecule inhibitors: A proof-of-concept study. J Med Virol. 2023 Jul;95(7):e28933.; https://hdl.handle.net/11351/10035Test |
| DOI: | 10.1002/jmv.28933 |
| الإتاحة: | https://doi.org/10.1002/jmv.28933Test https://hdl.handle.net/11351/10035Test |
| حقوق: | Attribution-NonCommercial 4.0 International ; http://creativecommons.org/licenses/by-nc/4.0Test/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.D6977015 |
| قاعدة البيانات: | BASE |
| تدمد: | 01466615 |
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| DOI: | 10.1002/jmv.28933 |