دورية أكاديمية
High omega-6/omega-3 fatty acid and oxylipin ratio in plasma is linked to an adverse cardiometabolic profile in middle-aged adults
| العنوان: | High omega-6/omega-3 fatty acid and oxylipin ratio in plasma is linked to an adverse cardiometabolic profile in middle-aged adults |
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| المؤلفون: | Jurado-Fasoli, Lucas, Osuna-Prieto, Francisco J., Yang, Wei, Kohler, Isabelle, Di, Xinyu, Rensen, Patrick C.N., Castillo, Manuel J., Martinez-Tellez, Borja, Amaro-Gahete, Francisco J. |
| المصدر: | Jurado-Fasoli , L , Osuna-Prieto , F J , Yang , W , Kohler , I , Di , X , Rensen , P C N , Castillo , M J , Martinez-Tellez , B & Amaro-Gahete , F J 2023 , ' High omega-6/omega-3 fatty acid and oxylipin ratio in plasma is linked to an adverse cardiometabolic profile in middle-aged adults ' , Journal of Nutritional Biochemistry , vol. 117 , 109331 , pp. 1-8 . https://doi.org/10.1016/j.jnutbio.2023.109331Test |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Cardiometabolic profile, Inflammation, Insulin resistance, Liver function, PUFAs, /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being |
| الوصف: | Omega-6 and omega-3 oxylipins may be surrogate markers of systemic inflammation, which is one of the triggers for the development of cardiometabolic disorders. In the current study, we investigated the relationship between plasma levels of omega-6 and omega-3 oxylipins with body composition and cardiometabolic risk factors in middle-aged adults. Seventy-two 72 middle-aged adults (39 women; 53.6±5.1 years old; 26.7±3.8 kg/m 2 ) were included in this cross-sectional study. Plasma levels of omega-6 and omega-3 fatty acids and oxylipins were determined using targeted lipidomic. Body composition, dietary intake, and cardiometabolic risk factors were assessed with standard methods. The plasma levels of the omega-6 fatty acids and derived oxylipins, the hydroxyeicosatetraenoic acids (HETEs; arachidonic acid (AA)-derived oxylipins) and dihydroxy-eicosatrienoic acids (DiHETrEs; AA-derived oxylipins), were positively associated with glucose metabolism parameters (i.e., insulin levels and homeostatic model assessment of insulin resistance index (HOMA); all r≥0.21, P<.05). In contrast, plasma levels of omega-3 fatty acids and derived oxylipins, specifically hydroxyeicosapentaenoic acids (HEPEs; eicosapentaenoic acid-derived oxylipins), as well as series-3 prostaglandins, were negatively associated with plasma glucose metabolism parameters (i.e., insulin levels, HOMA; all r≤0.20, P<.05). The plasma levels of omega-6 fatty acids and derived oxylipins, HETEs and DiHETrEs were also positively correlated with liver function parameters (i.e., glutamic pyruvic transaminase, gamma-glutamyl transferase (GGT), and fatty liver index; all r≥0.22 and P<.05). In addition, individuals with higher omega-6/omega-3 fatty acid and oxylipin ratio showed higher levels of HOMA, total cholesterol, low-density lipoprotein-cholesterol, triglycerides, and GGT (on average +36%), as well as lower levels of high-density lipoprotein cholesterol (-13%) (all P<.05). In conclusion, the omega-6/omega-3 fatty acid and oxylipin ratio, as well as ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://research.vu.nl/en/publications/cb2535b8-73b2-444b-9cec-e231ea852095Test |
| DOI: | 10.1016/j.jnutbio.2023.109331 |
| الإتاحة: | https://doi.org/10.1016/j.jnutbio.2023.109331Test https://research.vu.nl/en/publications/cb2535b8-73b2-444b-9cec-e231ea852095Test https://hdl.handle.net/1871.1/cb2535b8-73b2-444b-9cec-e231ea852095Test https://research.vu.nl/ws/files/291381454/High_omega-6_omega-3_fatty_acid_and_oxylipin_ratio_in_plasma_is_linked_to_an_adverse_cardiometabolic_profile_in_middle-aged_adults.pdfTest http://www.scopus.com/inward/record.url?scp=85152126822&partnerID=8YFLogxKTest http://www.scopus.com/inward/citedby.url?scp=85152126822&partnerID=8YFLogxKTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.D671B2F2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.jnutbio.2023.109331 |
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