دورية أكاديمية
Intermittently scanned continuous glucose monitoring in adults with type 1 diabetes:A subgroup analysis from the FLASH-UK study
| العنوان: | Intermittently scanned continuous glucose monitoring in adults with type 1 diabetes:A subgroup analysis from the FLASH-UK study |
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| المؤلفون: | Leelarathna, Lalantha, Sutton, Christopher J, Evans, Mark L, Neupane, Sankalpa, Rayman, Gerry, Lumley, Sarah, Cranston, Iain, Narendran, Parth, Krishan, Ashma, Taxiarchi, Vicky P, Barnard-Kelly, Katharine, Elliott, Rachel A, Burns, Matthew, Camm, Maisie, Thabit, Hood, Wilmot, Emma G |
| المصدر: | FLASH-UK Trial Study Group , Leelarathna , L , Sutton , C J , Evans , M L , Neupane , S , Rayman , G , Lumley , S , Cranston , I , Narendran , P , Krishan , A , Taxiarchi , V P , Barnard-Kelly , K , Elliott , R A , Burns , M , Camm , M , Thabit , H & Wilmot , E G 2023 , ' Intermittently scanned continuous glucose monitoring in adults with type 1 diabetes : A subgroup analysis from the FLASH-UK study ' , Diabetic medicine .... |
| سنة النشر: | 2023 |
| المجموعة: | The University of Manchester: Research Explorer - Publications |
| مصطلحات موضوعية: | continuous blood glucose monitoring, deprivation, insulin, type 1 diabetes |
| الوصف: | AIMS: The FLASH-UK trial showed lower HbA1c with intermittently scanned continuous glucose monitoring (isCGM), as compared with self monitoring of blood glucose (SMBG), in adults with type 1 diabetes and HbA1c ≥58 mmol/mol (≥7.5%). Here, we present results from the pre-specified subgroup analysis for the 24-week HbA1c (primary outcome) and selected sensor-based secondary outcomes. METHODS: This was a multi-centre, parallel-design, randomised controlled trial. The difference in treatment effect between subgroups (baseline HbA1c [≤75 vs. >75 mmol/mol] [≤9.0 vs >9.0%], treatment modality [pump vs injections], prior participation in structured education, age, educational level, impaired awareness of hypoglycaemia, deprivation index quintile sex, ethnic group and Patient Health Questionnaire-9 [PHQ-9] detected depression category) were evaluated. RESULTS: One hundred fifty-six participants (females 44%, mean [SD] baseline HbA1c 71 [9] mmol/mol 8.6 [0.8%], age 44 [15]) were randomly assigned, in a 1:1 ratio to isCGM (n = 78) or SMBG (n = 78). The mean (SD) baseline HbA1c (%) was 8.7 (0.9) in the isCGM group and 8.5 (0.8) in the SMBG group, lowering to 7.9 (0.8) versus 8.3 (0.9), respectively, at 24 weeks (adjusted mean difference -0.5, 95% confidence interval [CI] -0.7 to -0.3; p < 0.001]. For HbA1c, there was no impact of treatment modality, prior participation in structured education, deprivation index quintile, sex or baseline depression category. The between-group difference in HbA1c was larger for younger people (a reduction of 2.7 [95% CI 0.3-5.0; p = 0.028] mmol/mol for every additional 15 years of age). Those with HbA1c 76-97 mmol/mol (>9.0%-11.0%) had a marginally non-significant higher reduction in HbA1c of 8.4 mmol/mol (3.3-13.5) compared to 3.1 (0.3-6.0) in those with HbA1c 58-75 mmol/mol (p = 0.08). For 'Time in range' (% 3.9-10 mmol/L), the difference was larger for those with at least a bachelor's degree. For 'Time below range' (% <3.9 mmol/L), the difference was larger for those using ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://research.manchester.ac.uk/en/publications/3d243637-fc4c-4a8f-8202-666ac5bfe2c1Test |
| DOI: | 10.1111/dme.15249 |
| الإتاحة: | https://doi.org/10.1111/dme.15249Test https://research.manchester.ac.uk/en/publications/3d243637-fc4c-4a8f-8202-666ac5bfe2c1Test http://www.scopus.com/inward/record.url?scp=85176086003&partnerID=8YFLogxKTest https://www.mendeley.com/catalogue/419ad6fd-f800-3d47-84a0-dc83900a9423Test/ |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.D664C369 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/dme.15249 |
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