دورية أكاديمية
Controlled Antenatal Thyroid Screening II : Effect of Treating Maternal Suboptimal Thyroid Function on Child Behavior
| العنوان: | Controlled Antenatal Thyroid Screening II : Effect of Treating Maternal Suboptimal Thyroid Function on Child Behavior |
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| المؤلفون: | Hales C., Taylor P. N., Channon S., Mcewan K., Thapar A., Langley K., Muller I., Draman M. S., Dayan C., Gregory J. W., Okosieme O., Lazarus J. H., Rees D. A., Ludgate M. |
| المساهمون: | C. Hale, P.N. Taylor, S. Channon, K. Mcewan, A. Thapar, K. Langley, I. Muller, M.S. Draman, C. Dayan, J.W. Gregory, O. Okosieme, J.H. Lazaru, D.A. Ree, M. Ludgate |
| بيانات النشر: | Endocrine Society |
| سنة النشر: | 2020 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | ADHD, autism, childhood, pregnancy, thyroid, thyroxine, Adult, Attention Deficit Disorder with Hyperactivity, Biomarker, Case-Control Studie, Child, Child Behavior, Preschool, Cohort Studie, Female, Follow-Up Studie, Human, Hypothyroidism, Male, Prenatal Diagnosi, Prenatal Exposure Delayed Effect, Prognosi, Surveys and Questionnaire, Thyroid Function Test, United Kingdom, Mothers, Settore MED/13 - Endocrinologia |
| الوصف: | Context & Objectives: The Controlled Antenatal Thyroid Screening (CATS) study was the first randomized controlled trial to investigate effects of treating suboptimal gestational thyroid function (SGTF) on child cognition. Since observational studies indicated that SGTF may also increase symptoms of autism and attention-deficit/hyperactivity disorder (ADHD), the CATS cohort was used to investigate whether treatment of mothers affected their children's behavior. Design & Participants: Mothers (N = 475) completed 3 questionnaires: the Strengths and Difficulties Questionnaire (SDQ), the Child ADHD Questionnaire, and the Social Communication Questionnaire (SCQ, used as a screen for autism spectrum disorder [ASD]), about their children (mean age 9.5 years). Group comparisons of total scores, numbers of children above clinical thresholds, and association between high maternal free thyroxine (FT4) (> 97.5th percentile of the UK cohort, "overtreated") and child neurodevelopment were reported. Results: There were no differences in total scores between normal gestational thyroid function (GTF) (n = 246), treated (n = 125), and untreated (n = 104) SGTF groups. More children of treated mothers scored above clinical thresholds, particularly the overtreated. Scores were above thresholds in SDQ conduct (22% vs 7%), SCQ total scores (7% vs 1%), and ADHD hyperactivity (17% vs 5%) when comparing overtreated (n = 40) and untreated (N = 100), respectively. We identified significantly higher mean scores for SDQ conduct (adjusted mean difference [AMD] 0.74; 95% confidence interval [CI], 0.021-1.431; P = 0.040, effect size 0.018) and ADHD hyperactivity (AMD 1.60, 95% CI, 0.361-2.633; P = 0.003, effect size 0.028) comparing overtreated with normal-GTF children. Conclusions: There was no overall association between SGTF and offspring ADHD, ASD, or behavior questionnaire scores. However, children of "overtreated" mothers displayed significantly more ADHD symptoms and behavioral difficulties than those of normal-GTF mothers. ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/31665323; info:eu-repo/semantics/altIdentifier/wos/WOS:000525870500042; volume:105; issue:3; firstpage:e416; lastpage:e427; numberofpages:12; journal:THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM; http://hdl.handle.net/2434/806804Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85079203914 |
| DOI: | 10.1210/clinem/dgz098 |
| الإتاحة: | https://doi.org/10.1210/clinem/dgz098Test http://hdl.handle.net/2434/806804Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.D5F4ED6C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1210/clinem/dgz098 |
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