دورية أكاديمية

Cortical Macro‐ and Microstructural Changes in Parkinson's Disease with Probable Rapid Eye Movement Sleep Behavior Disorder

التفاصيل البيبلوغرافية
العنوان: Cortical Macro‐ and Microstructural Changes in Parkinson's Disease with Probable Rapid Eye Movement Sleep Behavior Disorder
المؤلفون: Pardo, Jèssica, Montal, Victor, Campabadal, Anna, Oltra, Javier, Uribe, Carme, Roura, Ignacio, Bargalló, Núria, Martí, Maria J., Compta, Yaroslau, Iranzo, Alex, Fortea, Juan, Junqué, Carme, Segura, Bàrbara
المساهمون: Ministerio de Economía y Competitividad, Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades, Generalitat de Catalunya, H2020 Marie Skłodowska-Curie Actions, 'la Caixa' Foundation, Ministerio de Ciencia e Innovación
المصدر: Movement Disorders ; ISSN 0885-3185 1531-8257
بيانات النشر: Wiley
سنة النشر: 2024
المجموعة: Wiley Online Library (Open Access Articles via Crossref)
الوصف: Background Evidence regarding cortical atrophy patterns in Parkinson's disease (PD) with probable rapid eye movement sleep behavior disorder (RBD) (PD‐pRBD) remains scarce. Cortical mean diffusivity (cMD), as a novel imaging biomarker highly sensitive to detecting cortical microstructural changes in different neurodegenerative diseases, has not been investigated in PD‐pRBD yet. Objectives The aim was to investigate cMD as a sensitive measure to identify subtle cortical microstructural changes in PD‐pRBD and its relationship with cortical thickness (CTh). Methods Twenty‐two PD‐pRBD, 31 PD without probable RBD (PD‐nonpRBD), and 28 healthy controls (HC) were assessed using 3D T1‐weighted and diffusion‐weighted magnetic resonance imaging on a 3‐T scanner and neuropsychological testing. Measures of cortical brain changes were obtained through cMD and CTh. Two‐class group comparisons of a general linear model were performed ( P < 0.05). Cohen's d effect size for both approaches was computed. Results PD‐pRBD patients showed higher cMD than PD‐nonpRBD patients in the left superior temporal, superior frontal, and precentral gyri, precuneus cortex, as well as in the right middle frontal and postcentral gyri and paracentral lobule ( d > 0.8), whereas CTh did not detect significant differences. PD‐pRBD patients also showed increased bilateral posterior cMD in comparison with HCs ( d > 0.8). These results partially overlapped with CTh results (0.5 < d < 0.8). PD‐nonpRBD patients showed no differences in cMD when compared with HCs but showed cortical thinning in the left fusiform gyrus and lateral occipital cortex bilaterally ( d > 0.5). Conclusions cMD may be more sensitive than CTh displaying significant cortico‐structural differences between PD subgroups, indicating this imaging biomarker's utility in studying early cortical changes in PD. © 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
نوع الوثيقة: article in journal/newspaper
اللغة: English
DOI: 10.1002/mds.29761
الإتاحة: https://doi.org/10.1002/mds.29761Test
حقوق: http://creativecommons.org/licenses/by-nc-nd/4.0Test/
رقم الانضمام: edsbas.D5C8F550
قاعدة البيانات: BASE