دورية أكاديمية
Transition between fermentation and respiration determines history-dependent behavior in fluctuating carbon sources
| العنوان: | Transition between fermentation and respiration determines history-dependent behavior in fluctuating carbon sources |
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| المؤلفون: | Cerulus, Bram, Jariani, Abbas, Perez-Samper, Gemma, Vermeersch, Lieselotte, Pietsch, Julian MJ, Crane, Matthew M, New, Aaron M, Gallone, Brigida, Roncoroni, Miguel, Dzialo, Maria C, Govers, Sander K, Hendrickx, Jhana O, Galle, Eva, Coomans, Maarten, Berden, Pieter, Verbandt, Sara, Swain, Peter S, Verstrepen, Kevin J |
| المساهمون: | Fonds Wetenschappelijk Onderzoek, Vlaams Instituut voor Biotechnologie, European Research Council, AB-InBev-Baillet Latour Fund, Human Frontier Science Program, SULSA Postdoctoral Exchange Scheme |
| المصدر: | eLife ; volume 7 ; ISSN 2050-084X |
| بيانات النشر: | eLife Sciences Publications, Ltd |
| سنة النشر: | 2018 |
| المجموعة: | eLife (E-Journal - via CrossRef) |
| الوصف: | Cells constantly adapt to environmental fluctuations. These physiological changes require time and therefore cause a lag phase during which the cells do not function optimally. Interestingly, past exposure to an environmental condition can shorten the time needed to adapt when the condition re-occurs, even in daughter cells that never directly encountered the initial condition. Here, we use the molecular toolbox of Saccharomyces cerevisiae to systematically unravel the molecular mechanism underlying such history-dependent behavior in transitions between glucose and maltose. In contrast to previous hypotheses, the behavior does not depend on persistence of proteins involved in metabolism of a specific sugar. Instead, presence of glucose induces a gradual decline in the cells’ ability to activate respiration, which is needed to metabolize alternative carbon sources. These results reveal how trans-generational transitions in central carbon metabolism generate history-dependent behavior in yeast, and provide a mechanistic framework for similar phenomena in other cell types. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.7554/elife.39234 |
| الإتاحة: | https://doi.org/10.7554/elife.39234Test https://cdn.elifesciences.org/articles/39234/elife-39234-v2.pdfTest https://cdn.elifesciences.org/articles/39234/elife-39234-v2.xmlTest https://elifesciences.org/articles/39234Test |
| حقوق: | http://creativecommons.org/licenses/by/4.0Test/ ; http://creativecommons.org/licenses/by/4.0Test/ ; http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.D5C27F40 |
| قاعدة البيانات: | BASE |
| DOI: | 10.7554/elife.39234 |
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