دورية أكاديمية
Key aspects of the Novartis compound collection enhancement project for the compilation of a comprehensive chemogenomics drug discovery screening collection.
| العنوان: | Key aspects of the Novartis compound collection enhancement project for the compilation of a comprehensive chemogenomics drug discovery screening collection. |
|---|---|
| المؤلفون: | Jacoby, Edgar, Schuffenhauer, Ansgar, Popov, Maxim, Azzaoui, Kamal, Havill, Benjamin, Schopfer, Ulrich, Engeloch, Caroline, Stanek, Jaroslav, Acklin, Pierre, Rigollier, Pascal, Stoll, Friederike, Koch, Guido, Meier, Peter, Orain, David, Giger, Rudolf K. A., Hinrichs, Juergen, Malagu, Karine, Zimmermann, Juerg, Roth, Hans-Joerg |
| بيانات النشر: | Bentham Science Publishers |
| سنة النشر: | 2005 |
| المجموعة: | The Novartis Repository (Novartis, Switzerland) |
| الوصف: | The NIBR (Novartis Institutes for BioMedical Research) compound collection enrichment and enhancement project integrates corporate internal combinatorial compound synthesis and external compound acquisition activities in order to build up a comprehensive screening collection for a modern drug discovery organization. The main purpose of the screening collection is to supply the Novartis drug discovery pipeline with hit-to-lead compounds for today's and the future's portfolio of drug discovery programs, and to provide tool compounds for the chemogenomics investigation of novel biological pathways and circuits. As such, it integrates designed focused and diversity-based compound sets from the synthetic and natural paradigms able to cope with druggable and currently deemed undruggable targets and molecular interaction modes. Herein, we will summarize together with new trends published in the literature, scientific challenges faced and key approaches taken at NIBR to match the chemical and biological spaces. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | Jacoby, Edgar, Schuffenhauer, Ansgar, Popov, Maxim, Azzaoui, Kamal, Havill, Benjamin, Schopfer, Ulrich, Engeloch, Caroline, Stanek, Jaroslav, Acklin, Pierre, Rigollier, Pascal, Stoll, Friederike, Koch, Guido, Meier, Peter, Orain, David, Giger, Rudolf K. A., Hinrichs, Juergen, Malagu, Karine, Zimmermann, Juerg and Roth, Hans-Joerg (2005) Key aspects of the Novartis compound collection enhancement project for the compilation of a comprehensive chemogenomics drug discovery screening collection. Current Topics in Medicinal Chemistry, 5 (4). pp. 397-411. ISSN 1568-0266; PMID: 15892682 |
| الإتاحة: | https://oak.novartis.com/637Test/ http://www.benthamdirect.org/pages/content.php?CTMC/2005/00000005/00000004/0004R.SGMTest |
| رقم الانضمام: | edsbas.D5B497E7 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |