دورية أكاديمية
Performance of a dual-hormone closed-loop system versus insulin-only closed-loop system in adolescents with type 1 diabetes. A single-blind, randomized, controlled, crossover trial
| العنوان: | Performance of a dual-hormone closed-loop system versus insulin-only closed-loop system in adolescents with type 1 diabetes. A single-blind, randomized, controlled, crossover trial |
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| المؤلفون: | Lindkvist, Emilie Bundgaard, Laugesen, Christian, Reenberg, Asbjørn Thode, Ritschel, Tobias Kasper Skov, Svensson, Jannet, Jørgensen, John Bagterp, Nørgaard, Kirsten, Ranjan, Ajenthen G. |
| المصدر: | Lindkvist , E B , Laugesen , C , Reenberg , A T , Ritschel , T K S , Svensson , J , Jørgensen , J B , Nørgaard , K & Ranjan , A G 2023 , ' Performance of a dual-hormone closed-loop system versus insulin-only closed-loop system in adolescents with type 1 diabetes. A single-blind, randomized, controlled, crossover trial ' , Frontiers in Endocrinology , vol. 14 , 1073388 . https://doi.org/10.3389/fendo.2023.1073388Test |
| سنة النشر: | 2023 |
| المجموعة: | Technical University of Denmark: DTU Orbit / Danmarks Tekniske Universitet |
| مصطلحات موضوعية: | Adolescents, Advanced hybrid closed-loop, Artificial pancreas, Dual-hormone, Moderate intensity continuous exercise, Non-linear model predictive control, Type 1 diabetes mellitus, /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being |
| الوصف: | Objective : To assess the efficacy and safety of a dual-hormone (DH [insulin and glucagon]) closed-loop system compared to a single-hormone (SH [insulin only]) closed-loop system in adolescents with type 1 diabetes. Methods : This was a 26-hour, two-period, randomized, crossover, inpatient study involving 11 adolescents with type 1 diabetes (nine males [82%], mean ± SD age 14.8 ± 1.4 years, diabetes duration 5.7 ± 2.3 years). Except for the treatment configuration of the DiaCon Artificial Pancreas: DH or SH, experimental visits were identical consisting of: an overnight stay (10:00 pm until 7:30 am), several meals/snacks, and a 45-minute bout of moderate intensity continuous exercise. The primary endpoint was percentage of time spent with sensor glucose values below range (TBR [<3.9 mmol/L]) during closed-loop control over the 26-h period (5:00 pm, day 1 to 7:00 pm, day 2). Results : Overall, there were no differences between DH and SH for the following glycemic outcomes (median [IQR]): TBR 1.6 [0.0, 2.4] vs. 1.28 [0.16, 3.19]%, p=1.00; time in range (TIR [3.9-10.0 mmol/L]) 68.4 [48.7, 76.8] vs. 75.7 [69.8, 87.1]%, p=0.08; and time above range (TAR [>10.0 mmol/L]) 28.1 [18.1, 49.8] vs. 23.3 [12.3, 27.2]%, p=0.10. Mean (± SD) glucose was higher during DH than SH (8.7 (± 3.2) vs. 8.1 (± 3.0) mmol/L, p<0.001) but coefficient of variation was similar (34.8 (± 6.8) vs. 37.3 (± 8.6)%, p=0.20). The average amount of rescue carbohydrates was similar between DH and SH (6.8 (± 12.3) vs. 9.5 (± 15.4) grams/participant/visit, p=0.78). Overnight, TIR was higher, TAR was lower during the SH visit compared to DH. During and after exercise (4:30 pm until 7 pm) the SH configuration produced higher TIR, but similar TAR and TBR compared to the DH configuration. Conclusions : DH and SH performed similarly in adolescents with type 1 diabetes during a 26-hour inpatient monitoring period involving several metabolic challenges including feeding and exercise. However, during the night and around exercise, the SH configuration ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://orbit.dtu.dk/en/publications/60e9b46b-3bf3-426b-91e7-fd5f54b2ba55Test |
| DOI: | 10.3389/fendo.2023.1073388 |
| الإتاحة: | https://doi.org/10.3389/fendo.2023.1073388Test https://orbit.dtu.dk/en/publications/60e9b46b-3bf3-426b-91e7-fd5f54b2ba55Test https://backend.orbit.dtu.dk/ws/files/311073129/fendo_14_1073388.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.D596ED9C |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fendo.2023.1073388 |
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