التفاصيل البيبلوغرافية
| العنوان: |
Correlation of expression of BP1, a homeobox gene, with estrogen receptor status in breast cancer |
| المؤلفون: |
Fu, Sidney W, Schwartz, Arnold, Stevenson, Holly, Pinzone, Joseph J, Davenport, Gregory J, Orenstein, Jan M, Gutierrez, Peter, Simmens, Samuel J, Abraham, Jessy, Poola, Indira, Stephan, Dietrich A, Berg, Patricia E |
| بيانات النشر: |
BioMed Central Ltd. |
| سنة النشر: |
2003 |
| المجموعة: |
BioMed Central |
| مصطلحات موضوعية: |
BP1, breast cancer, distal-less, estrogen receptor, homeobox |
| الوصف: |
Background BP1 is a novel homeobox gene cloned in our laboratory. Our previous studies in leukemia demonstrated that BP1 has oncogenic properties, including as a modulator of cell survival. Here BP1 expression was examined in breast cancer, and the relationship between BP1 expression and clinicopathological data was determined. Methods Total RNA was isolated from cell lines, tumors, and matched normal adjacent tissue or tissue from autopsy. Reverse transcription polymerase chain reaction was performed to evaluate BP1 expression. Statistical analysis was accomplished with SAS. Results Analysis of 46 invasive ductal breast tumors demonstrated BP1 expression in 80% of them, compared with a lack of expression in six normal breast tissues and low-level expression in one normal breast tissue. Remarkably, 100% of tumors that were negative for the estrogen receptor (ER) were BP1-positive, whereas 73% of ER-positive tumors expressed BP1 ( P = 0.03). BP1 expression was also associated with race: 89% of the tumors of African American women were BP1-positive, whereas 57% of those from Caucasian women expressed BP1 ( P = 0.04). However, there was no significant difference in BP1 expression between grades I, II, and III tumors. Interestingly, BP1 mRNA expression was correlated with the ability of malignant cell lines to cause breast cancer in mice. Conclusion Because BP1 is expressed abnormally in breast tumors, it could provide a useful target for therapy, particularly in patients with ER-negative tumors. The frequent expression of BP1 in all tumor grades suggests that activation of BP1 is an early event. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| العلاقة: |
http://breast-cancer-research.com/content/5/4/R82Test |
| الإتاحة: |
http://breast-cancer-research.com/content/5/4/R82Test |
| حقوق: |
Copyright 2003 Fu et al., licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. |
| رقم الانضمام: |
edsbas.D57C3F40 |
| قاعدة البيانات: |
BASE |
