التفاصيل البيبلوغرافية
| العنوان: |
Impaired exocrine pancreatic function in different stages of type 1 diabetes |
| المؤلفون: |
Dozio, Nicoletta, Indirli, Rita, Giamporcaro, Gian Maria, Frosio, Laura, Mandelli, Alessandra, Laurenzi, Andrea, Bolla, Andrea Mario, Stabilini, Angela, Valle, Andrea, Locatelli, Massimo, Cavestro, Giulia Martina, Scavini, Marina, Battaglia, Manuela, Bosi, Emanuele |
| المصدر: |
BMJ Open Diabetes Research & Care ; volume 9, issue 1, page e001158 ; ISSN 2052-4897 |
| بيانات النشر: |
BMJ |
| سنة النشر: |
2021 |
| الوصف: |
Introduction Aim of this study was to investigate the pancreatic exocrine function in patients with type 1 diabetes (T1D) by multiple non-invasive tests. Research design and methods The study is a single-center, cross-sectional study of pancreatic exocrine function in adult patients with new-onset or long-standing T1D and healthy controls. Results Healthy controls, new-onset T1D, and long-standing T1D were similar for age at the time of the study, gender and body mass index (BMI) categories. Age of onset of T1D patients with long-standing disease was younger than that of patients with new-onset T1D (p<0.001). As expected, the three groups differed for C-peptide and hemoglobin A1c (HbA1c) levels. Lipase activity measured by 13 C-mixed triglyceride breath test was reduced progressively, although not significantly, from controls to recent-onset T1D and long-standing T1D participants. Fecal elastase-1 was significantly lower in participants with T1D, either new onset or long standing. Pancreatic amylase, lipase, retinol binding protein and prealbumin were significantly different across the groups, with a significant trend toward lower values in long-standing T1D and intermediate values in new-onset T1D, while no differences were observed for total amylase. The markers of impaired exocrine function tests (fecal elastase-1, serum pancreatic amylase and lipase) and of nutritional status (retinol binding protein and prealbumin levels) correlated with the reduction of fasting and urinary C-peptide. Conclusions Our results confirm that exocrine pancreatic impairment is a feature of T1D, with low fecal elastase-1, serum pancreatic amylase and lipase as specific markers, associated with reduced levels of nutritional indexes. Moreover, the evidence of more advanced insufficiency in long-standing disease reflects the chronic nature of this process, and its correlation with the residual β-cell function suggests parallel pathways for the impairment of the endocrine and exocrine pancreatic function. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1136/bmjdrc-2019-001158 |
| الإتاحة: |
https://doi.org/10.1136/bmjdrc-2019-001158Test |
| حقوق: |
http://creativecommons.org/licenses/by-nc/4.0Test/ |
| رقم الانضمام: |
edsbas.D5383353 |
| قاعدة البيانات: |
BASE |
