دورية أكاديمية
Pathophysiological Integration of Metabolic Reprogramming in Breast Cancer
| العنوان: | Pathophysiological Integration of Metabolic Reprogramming in Breast Cancer |
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| المؤلفون: | Corchado Cobos, Roberto, García Sancha, Natalia, Mendiburu Eliçabe, Marina, Gómez Vecino, Aurora, Jiménez Navas, Alejandro, Pérez Baena, Manuel Jesús, Holgado Madruga, Marina, Mao, Jian Hua, Cañueto Álvarez, Javier, Castillo Lluva, Sonia, Pérez Losada, Jesús |
| بيانات النشر: | MPDI |
| سنة النشر: | 2022 |
| المجموعة: | Universidad Complutense de Madrid (UCM): E-Prints Complutense |
| مصطلحات موضوعية: | 616-006.04, Metabolism, interstitium, glucose, lactate, hypoxia, cancer-associated fibroblasts, macrophages, Oncología, Psicología (Psicología), 3201.01 Oncología, 61 Psicología |
| الوصف: | Metabolic changes that facilitate tumor growth are one of the hallmarks of cancer. The triggers of these metabolic changes are located in the tumor parenchymal cells, where oncogenic mutations induce an imperative need to proliferate and cause tumor initiation and progression. Cancer cells undergo significant metabolic reorganization during disease progression that is tailored to their energy demands and fluctuating environmental conditions. Oxidative stress plays an essential role as a trigger under such conditions. These metabolic changes are the consequence of the interaction between tumor cells and stromal myofibroblasts. The metabolic changes in tumor cells include protein anabolism and the synthesis of cell membranes and nucleic acids, which all facilitate cell proliferation. They are linked to catabolism and autophagy in stromal myofibroblasts, causing the release of nutrients for the cells of the tumor parenchyma. Metabolic changes lead to an interstitium deficient in nutrients, such as glucose and amino acids, and acidification by lactic acid. Together with hypoxia, they produce functional changes in other cells of the tumor stroma, such as many immune subpopulations and endothelial cells, which lead to tumor growth. Thus, immune cells favor tissue growth through changes in immunosuppression. This review considers some of the metabolic changes described in breast cancer. ; Ministerio de Ciencia e Innovación (España) ; Instituto de Salud Carlos III ; Junta de Castilla y León ; Federación Española de Enfermedades Raras ; Depto. de Bioquímica y Biología Molecular ; Fac. de Ciencias Químicas ; TRUE ; pub |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2072-6694 |
| العلاقة: | info:eu-repo/grantAgreement/MCIN/AEI/10.13039/501100011039; info:eu-repo/grantAgreement/PI18/00587; info:eu-repo/grantAgreement/GRS2139/A/20; info:eu-repo/grantAgreement/SAF2017-88854R; info:eu-repo/grantAgreement/RTI2018-094130-B-100; info:eu-repo/grantAgreement/PID2020-118527RB-I00 i; info:eu-repo/grantAgreement/PI21/01207; info:eu-repo/grantAgreement/PIE14/00066; info:eu-repo/grantAgreement/CSI234P18; info:eu-repo/grantAgreement/CSI144P20; info:eu-repo/grantAgreement/PDC2021-121735-I00; https://hdl.handle.net/20.500.14352/72070Test; Corchado-Cobos R, García-Sancha N, Mendiburu-Eliçabe M, Gómez-Vecino A, Jiménez-Navas A, Pérez-Baena MJ, et al. Pathophysiological Integration of Metabolic Reprogramming in Breast Cancer. Cancers 2022;14:322. https://doi.org/10.3390/cancers14020322Test.; https://doi.org/10.3390/cancers14020322Test; https://www.mdpi.com/2072-6694/14/2/322/htmTest |
| DOI: | 10.3390/cancers14020322 |
| الإتاحة: | https://doi.org/20.500.14352/7207010.3390/cancers14020322Test https://hdl.handle.net/20.500.14352/72070Test https://www.mdpi.com/2072-6694/14/2/322/htmTest |
| حقوق: | ATTRIBUTION 4.0 INTERNATIONAL ; https://creativecommons.org/licenses/by/4.0Test/ ; open access |
| رقم الانضمام: | edsbas.D49E02FF |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20726694 |
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| DOI: | 10.3390/cancers14020322 |