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Rolipram improves facilitation of contextual fear extinction in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease

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العنوان: Rolipram improves facilitation of contextual fear extinction in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease
المؤلفون: Kinoshita, Ken-ichi, Muroi, Yoshikage, Unno, Toshihiro, Ishii, Toshiaki
بيانات النشر: Japanese Pharmacological Society
سنة النشر: 2017
المجموعة: Obihiro University: Obihiro Archives of Knowledge (OAK) / 帯広畜産大学学術情報リポジトリ
مصطلحات موضوعية: Memory extinction, MPTP-Treated mice, Phosphodiesterase IV inhibitor rolipram
الوقت: 645
الوصف: application/pdf ; Cognitive impairment often occurs in Parkinson's disease (PD), but the mechanism of onset remains unknown. Recently, we reported that PD model mice produced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) show facilitation of hippocampal memory extinction, which may be the cause of cognitive impairment in PD. When we examined the cAMP/CREB signaling in the hippocampus, decreased levels of cAMP and phosphorylated CREB were observed in the dentate gyrus (DG) of MPTP-treated mice. Administration of rolipram improved the memory deficits with concomitant recovery of cAMP and phosphorylated CREB levels, suggesting that reduced cAMP/CREB signaling in the DG leads to cognitive impairment in MPTP-treated mice. (C) 2017 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society. ; journal article
نوع الوثيقة: other/unknown material
وصف الملف: application/pdf
اللغة: English
تدمد: 13478613
العلاقة: Journal of Pharmacological Sciences; 134; 55; 58; AA11806667; https://obihiro.repo.nii.ac.jp/record/1281/files/1-s2.0-S1347861317300580-main.pdfTest
الإتاحة: https://doi.org/10.1016/j.jphs.2017.04.002Test
https://obihiro.repo.nii.ac.jp/record/1281/files/1-s2.0-S1347861317300580-main.pdfTest
حقوق: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0Test/).
رقم الانضمام: edsbas.D425BAE
قاعدة البيانات: BASE
الوصف
تدمد:13478613