التفاصيل البيبلوغرافية
| العنوان: |
Genome-wide association analysis identifies three new breast cancer susceptibility loci |
| المؤلفون: |
Ghoussaini M, Luccarini C, Mannermaa A, Kataja V, Kosma VM, Hartikainen JM, Lambrechts D, Yesilyurt BT, Floris G, Leunen K, Manoukian S, Hall P, Tsimiklis H, Makalic E, Margolin S, Turnbull C, Schmidt D, Bui M, Hopper JL, Baynes C, Apicella C, Lindblom A, Park DJ, Southey M, Hunter DJ, Chanock SJ, Giles GG, Broeks A, Verhoef S, Schmidt MK, Hogervorst FB, Fasching PA, Borrensen-Dale AL, Fortuzzi S, Lux MP, Beckmann MW, Ekici AB, Sawyer E, Baglietto L, Tomlinson I, Kerin M, Marme F, Schneeweiss A, John EM, Dicks E, Sohn C, Peterlongo P, Burwinkel B, Guenel P, Truong T, Severi G, Cordina-Duverger E, Menegaux F, Bojesen SE, Irwanto A, Nordestgaard BG, Nielsen SF, Flyger H, Dennis J, Couch FJ, Milne RL, Alonso MR, McLean C, Gonzalez-Neira A, Benitez J, Miron A, Anton-Culver H, Ziogas A, Bernstein L, Dur CC, Brenner H, Muller H, Wang X, Wang Q, Conroy D, Arndt V, Winqvist R, Stegmaier C, Justenhoven C, Brauch H, Bruning T, Wang-Gohrke S, Eilber U, Dork T, Schurmann P, Stevens K, Alnaes GG, Pylkas K, Bremer M, Humphreys MK, Hillemanns P, Bogdanova NV, Antonenkova NN, Rogov YI, Karstens JH, Bermisheva M, Prokofieva D, Khusnutdinova E, Jukkola-Vuorinen A, Kristensen V, Lee A, Kauppila S, Andrulis IL, Czene K, Maranian M, Glendon G, Mulligan AM, Devilee P, Liu J, van Asperen CJ, Tollenaar RA, Seynaeve C, Figueroa JD, Garcia-Closas M, Muller-Myhsok B, Brinton L, Lissowska J, Ahmed S, Hooning MJ, Hollestelle A, Nevanlinna H, Oldenburg RA, van den Ouweland AM, Cox A, Reed MW, Lichtner P, Shah M, Jakubowska A, Lubinski J, Jaworska K, Driver K, Durda K, Aittomaki K, Jones M, Schoemaker M, Ashworth A, Bonanni B, Swerdlow A, Beesley J, Chen X, Muir KR, Lophatananon A, Rattanamongkongul S, Johnson N, Blomqvist C, Chaiwerawattana A, Kang D, Chang-Claude J, Yoo KY, Noh DY, Shen CY, Yu JC, Wu PE, Hsiung CN, Perkins A, Swann R, Michailidou K, Orr N, Hein R, Velentzis L, Eccles DM, Tapper WJ, Gerty SM, Graham NJ, Ponder BA, Chenevix-Trench G, Pharoah PD, Lathrop M, Meindl A, Nickels S, Dunning AM, dos Santos Silva I, Rahman N, Peto J, Easton DF, Waisfisz Q, Fletcher O, Meijers-Heijboer H, Uitterlinden AG, Rivadeneira F, Flesch-Janys D, Schmutzler RK |
| بيانات النشر: |
Nature Genetics |
| سنة النشر: |
2012 |
| المجموعة: |
The University of Sydney: Sydney eScholarship Repository |
| مصطلحات موضوعية: |
analysis, Genetic Loci, Genetic Predisposition to Disease, genetics, Genome-Wide Association Study, Humans, Logistic Models, Meta-Analysis, Other, Polymorphism,Single Nucleotide, Principal Component Analysis, breast, Risk, Women, Breast Neoplasms, cancer, Chromosomes,Human,Pair 12, Chromosomes,Human,Pair 21, epidemiology, European Continental Ancestry Group, Female, Cancer Type - Breast Cancer, Treatment - Localised Therapies – Discovery and Development |
| الوصف: |
Breast cancer is the most common cancer among women. To date, 22 common breast cancer susceptibility loci have been identified accounting for approximately 8% of the heritability of the disease. We attempted to replicate 72 promising associations from two independent genome-wide association studies (GWAS) in approximately 70,000 cases and approximately 68,000 controls from 41 case-control studies and 9 breast cancer GWAS. We identified three new breast cancer risk loci at 12p11 (rs10771399; P = 2.7 x 10(-35)), 12q24 (rs1292011; P = 4.3 x 10(-19)) and 21q21 (rs2823093; P = 1.1 x 10(-12)). rs10771399 was associated with similar relative risks for both estrogen receptor (ER)-negative and ER-positive breast cancer, whereas the other two loci were associated only with ER-positive disease. Two of the loci lie in regions that contain strong plausible candidate genes: PTHLH (12p11) has a crucial role in mammary gland development and the establishment of bone metastasis in breast cancer, and NRIP1 (21q21) encodes an ER cofactor and has a role in the regulation of breast cancer cell growth |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
See Supplementary Note: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653403/bin/NIHMS40160-supplement-1.pdfTest; https://hdl.handle.net/2123/30605Test; https://doi.org/10.1038/ng.1049Test |
| DOI: |
10.1038/ng.1049 |
| الإتاحة: |
https://doi.org/10.1038/ng.1049Test
https://hdl.handle.net/2123/30605Test |
| رقم الانضمام: |
edsbas.D402BA50 |
| قاعدة البيانات: |
BASE |
