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Impact of SARS-CoV-2 vaccines and recent chemotherapy on COVID-19 morbidity and mortality in patients with soft tissue sarcoma: an analysis from the OnCovid registry

التفاصيل البيبلوغرافية
العنوان: Impact of SARS-CoV-2 vaccines and recent chemotherapy on COVID-19 morbidity and mortality in patients with soft tissue sarcoma: an analysis from the OnCovid registry
المؤلفون: Vincenzi, Bruno, Cortellini, Alessio, Mazzocca, Alessandro, Orlando, Sarah, Romandini, Davide, Aguilar Company, Juan, Ruiz Camps, Isabel, Valverde Morales, Claudia, Eremiev Eremiev, Simeon, Tondini, Carlo, Brunet, Joan, Bertulli, Rossella, Provenzano, Salvatore, Bower, Mark, Generali, Daniele, Salazar, Ramon, Sureda, Anna, Prat, Aleix, Vasiliki, Michalarea, Hemelrijck, Mieke Van, Sita Lumsden, Ailsa, Bertuzzi, Alexia, Rossi, Sabrina, Jackson, Amanda, Grosso, Federica, Lee, Alvin J. X., Murphy, Cian, Belessiotis, Katherine, Mukherjee, Uma, Pommeret, Fanny, Loizidou, Angela, Gaidano, Gianluca, Dettorre, Gino M., Grisanti, Salvatore, Tucci, Marco, Fulgenzi, Claudia A. M., Gennari, Alessandra, Napolitano, Andrea, Pinato, David J.
المصدر: Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
بيانات النشر: SAGE Publications
سنة النشر: 2024
المجموعة: Dipòsit Digital de la Universitat de Barcelona
مصطلحات موضوعية: SARS-CoV-2, Quimioteràpia, Chemotherapy
الوصف: Background: To date, limited evidence exists on the impact of COVID-19 in patients with soft tissue sarcoma (STS), nor about the impact of SARS-CoV-2 vaccines and recent chemotherapy on COVID-19 morbidity and mortality in this specific population.Methods: We described COVID-19 morbidity and mortality among patients with STS across 'Omicron' (15 December 2021-31 January 2022), 'Pre-vaccination' (27 February 2020-30 November 2020), and 'Alpha-Delta' phase (01 December 2020-14 December 2021) using OnCovid registry participants (NCT04393974). Case fatality rate at 28 days (CFR28) and COVID-19 severity were also described according to the SARS-CoV-2 vaccination status, while the impact of the receipt of cytotoxic chemotherapy within 4 weeks prior to COVID-19 on clinical outcomes was assessed with Inverse Probability of Treatment Weighting (IPTW) models adjusted for possible confounders.Results: Out of 3820 patients, 97 patients with STS were included. The median age at COVID-19 diagnosis was 56 years (range: 18-92), with 65 patients (67%) aged < 65 years and most patients had a low comorbidity burden (65, 67.0%). The most frequent primary tumor sites were the abdomen (56.7%) and the gynecological tract (12.4%). In total, 36 (37.1%) patients were on cytotoxic chemotherapy within 4 weeks prior to COVID-19. The overall CFR28 was 25.8%, with 38% oxygen therapy requirement, 34% rate of complications, and 32.3% of hospitalizations due to COVID-19. CFR28 (29.5%, 21.4%, and 12.5%) and all indicators of COVID-19 severity demonstrated a trend toward a numerical improvement across the pandemic phases. Similarly, vaccinated patients demonstrated numerically improved CFR28 (16.7% versus 27.7%) and COVID-19 morbidity compared with unvaccinated patients. Patients who were on chemotherapy experienced comparable CFR28 (19.4% versus 26.0%, p = 0.4803), hospitalizations (50.0% versus 44.4%, p = 0.6883), complication rates (30.6% versus 34.0%, p = 0.7381), and oxygen therapy requirement (28.1% versus 40.0%, p = 0.2755) compared to ...
نوع الوثيقة: article in journal/newspaper
وصف الملف: 11 p.; application/pdf
اللغة: English
تدمد: 1758-8359
العلاقة: Reproducció del document publicat a: https://doi.org/10.1177/17588359231225028Test; Therapeutic Advances in Medical Oncology, 2024, vol. 16; https://doi.org/10.1177/17588359231225028Test; http://hdl.handle.net/2445/207224Test
الإتاحة: https://doi.org/10.1177/17588359231225028Test
http://hdl.handle.net/2445/207224Test
حقوق: cc by-nc (c) Vincenzi, Bruno et al., 2024 ; http://creativecommons.org/licenses/by-nc/3.0/esTest/ ; info:eu-repo/semantics/openAccess
رقم الانضمام: edsbas.D3CFEC25
قاعدة البيانات: BASE
الوصف
تدمد:17588359