دورية أكاديمية
Deficiency in Tissue Non-Specific Alkaline Phosphatase Leads to Steatohepatitis in Mice Fed a High Fat Diet Similar to That Produced by a Methionine and Choline Deficient Diet
| العنوان: | Deficiency in Tissue Non-Specific Alkaline Phosphatase Leads to Steatohepatitis in Mice Fed a High Fat Diet Similar to That Produced by a Methionine and Choline Deficient Diet |
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| المؤلفون: | Reyes Gámez-Belmonte, Mireia Tena-Garitaonaindia, Cristina Hernández-Chirlaque, Samir Córdova, Diego Ceacero-Heras, Fermín Sánchez de Medina, Olga Martínez-Augustin |
| المصدر: | International Journal of Molecular Sciences, Vol 22, Iss 51, p 51 (2020) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2020 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | methionine and choline diet, metabolic syndrome, biliary acids, tissue non-specific alkaline phosphatase, steatohepatitis, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | The liver expresses tissue-nonspecific alkaline phosphatase (TNAP), which may participate in the defense against bacterial components, in cell regulation as part of the purinome or in bile secretion, among other roles. We aimed to study the role of TNAP in the development of hepatosteatosis. TNAP +/− haplodeficient and wild type (WT) mice were fed a control diet (containing 10% fat w/w ) or the same diet deficient in methionine and choline (MCD diet). The MCD diet induced substantial weight loss together with hepatic steatosis and increased alanine aminotransferase (ALT) plasma levels, but no differences in IL-6, TNF, insulin or resistin. There were no substantial differences between TNAP +/− and WT mice fed the MCD diet. In turn, TNAP +/− mice receiving the control diet presented hepatic steatosis with alterations in metabolic parameters very similar to those induced by the MCD diet. Nevertheless, no weight loss, increased ALT plasma levels or hypoglycemia were observed. These mice also presented increased levels of liver TNF and systemic resistin and glucagon compared to WT mice. The phenotype of TNAP +/− mice fed a standard diet was normal. In conclusion, TNAP haplodeficiency induces steatosis comparable to that produced by a MCD diet when fed a control diet. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| العلاقة: | https://www.mdpi.com/1422-0067/22/1/51Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test; https://doaj.org/article/367873a338d74f3e894362e22376bf39Test |
| DOI: | 10.3390/ijms22010051 |
| الإتاحة: | https://doi.org/10.3390/ijms22010051Test https://doaj.org/article/367873a338d74f3e894362e22376bf39Test |
| رقم الانضمام: | edsbas.D3A88E87 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms22010051 |