دورية أكاديمية
Genome-wide association study identifies susceptibility loci for acute myeloid leukemia.
| العنوان: | Genome-wide association study identifies susceptibility loci for acute myeloid leukemia. |
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| المؤلفون: | Lin, W.Y., Fordham, S.E., Hungate, E., Sunter, N.J., Elstob, C., Xu, Y., Park, C., Quante, A.S., Strauch, K., Gieger, C., Skol, A., Rahman, T., Sucheston-Campbell, L., Wang, J., Hahn, T., Clay-Gilmour, A.I., Jones, G.L., Marr, H.J., Jackson, G.H., Menne, T., Collin, M., Ivey, A., Hills, R.K., Burnett, A.K., Russell, N.H., Fitzgibbon, J., Larson, R.A., Le Beau, M.M., Stock, W., Heidenreich, O., Alharbi, A., Allsup, D.J., Houlston, R.S., Norden, J., Dickinson, A.M., Douglas, E., Lendrem, C., Daly, A.K., Palm, L., Piechocki, K., Jeffries, S., Bornhäuser, M., Röllig, C., Altmann, H., Ruhnke, L., Kunadt, D., Wagenführ, L., Cordell, H.J., Darlay, R., Andersen, M.K., Fontana, M.C., Martinelli, G., Marconi, G., Sanz, M.A., Cervera, J., Gómez-Seguí, I., Cluzeau, T., Moreilhon, C., Raynaud, S., Sill, H., Voso, M.T., Lo-Coco, F., Dombret, H., Cheok, M., Preudhomme, C., Gale, R.E., Linch, D., Gaal-Wesinger, J., Masszi, A., Nowak, D., Hofmann, W.K., Gilkes, A., Porkka, K., Milosevic Feenstra, J.D., Kralovics, R., Grimwade, D., Meggendorfer, M., Haferlach, T., Krizsán, S., Bödör, C., Stölzel, F., Onel, K., Allan, J.M. |
| المصدر: | Nat. Commun. 12:6233 (2021) |
| بيانات النشر: | Nature Portfolio |
| سنة النشر: | 2021 |
| المجموعة: | PuSH - Publikationsserver des Helmholtz Zentrums München |
| الوصف: | Acute myeloid leukemia (AML) is a hematological malignancy with an undefined heritable risk. Here we perform a meta-analysis of three genome-wide association studies, with replication in a fourth study, incorporating a total of 4018 AML cases and 10488 controls. We identify a genome-wide significant risk locus for AML at 11q13.2 (rs4930561; P = 2.15 × 10-8; KMT5B). We also identify a genome-wide significant risk locus for the cytogenetically normal AML sub-group (N = 1287) at 6p21.32 (rs3916765; P = 1.51 × 10-10; HLA). Our results inform on AML etiology and identify putative functional genes operating in histone methylation (KMT5B) and immune function (HLA). |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2041-1723 |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/34716350; info:eu-repo/semantics/altIdentifier/wos/WOS:000712910500011; info:eu-repo/semantics/altIdentifier/isbn/2041-1723; info:eu-repo/semantics; https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=63433Test; urn:isbn:2041-1723; urn:issn:2041-1723 |
| DOI: | 10.1038/s41467-021-26551-x |
| الإتاحة: | https://doi.org/10.1038/s41467-021-26551-xTest https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=63433Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.D375C6D8 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20411723 |
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| DOI: | 10.1038/s41467-021-26551-x |