دورية أكاديمية
18F-FET and 18F-choline PET-CT in patients with MRI-suspected low-grade gliomas: a pilot study
| العنوان: | 18F-FET and 18F-choline PET-CT in patients with MRI-suspected low-grade gliomas: a pilot study |
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| المؤلفون: | Mišir Krpan, Ana, Hodolič, Marina, Golubić, Anja Tea, Baučić, Maja, Nemir, Jakob, Mrak, Goran, Žuvić, Marijan, Huić, Dražen |
| المصدر: | Croatian Medical Journal ; ISSN 0353-9504 (Print) ; ISSN 1332-8166 (Online) ; Volume 62 ; Issue 4 |
| سنة النشر: | 2021 |
| المجموعة: | Hrčak - Portal of scientific journals of Croatia / Portal znanstvenih časopisa Republike Hrvatske |
| الوصف: | Aim To investigate the diagnostic accuracy of O-(2-[18F]- fluoroethyl)-L-tyrosine (18F-FET) and fluoromethyl-(18F)- dimethyl-2-hydroxyethyl-ammonium chloride (18F-FCH) computed tomography (CT) in patients with primary lowgrade gliomas (LGG). Methods The study enrolled patients with magnetic resonance imaging (MRI)-suspected LGG. Patients underwent both 18F-FET and 18F-FCH positron emission tomography (PET)-CT. Brain PET-CT was performed according to standard protocol – 20 minutes after intravenous injection of 185 MBq of 18F-FET and 185 MBq of 18F-FCH PET. Surgery and pathohistological diagnosis were performed in the next two weeks. Results We observed significantly better concordance between tumor histology and 18F-FET PET (weighted Kappa 0.74) compared with both 18F-FCH (weighted Kappa 0.15) and MRI (weighted Kappa 0.00). Tumor histology was significantly associated with 18F-FET (odds ratio 12.87; 95% confidence interval [CI], 0.49-333.70; P=0.013, logistic regression analysis). Receiver operating characteristic curve analysis comparing 18F-FCH (area under the curve [AUC] 0.625, 95% CI 0.298-0.884) and 18F-FET (AUC 0.833, 95% CI 0.499-0.982) showed better diagnostic properties of 18F-FET (AUC difference 0.208, 95% CI -0.145 to 0.562, P=0.248). Conclusion Performing PET-CT in patients with newly diagnosed LGG should be preceded by a selection of an appropriate radiopharmaceutical. 18F-FET seems to be more accurate than 18F-FCH in the LGG diagnosis |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://hrcak.srce.hr/278144Test |
| الإتاحة: | https://doi.org/10.3325/cmj.2021.62.310Test https://hrcak.srce.hr/278144Test https://hrcak.srce.hr/file/402814Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.D33CE418 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |