دورية أكاديمية
Early postnatal genistein administration affects mice metabolism and reproduction in a sexually dimorphic way
| العنوان: | Early postnatal genistein administration affects mice metabolism and reproduction in a sexually dimorphic way |
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| المؤلفون: | Marraudino, Marilena, Ponti, Giovanna, Moussu, Chantal, Farinetti, Alice, Macchi, Elisabetta, Accornero, Paolo, Gotti, Stefano, Collado, Paloma, Keller, Matthieu, Panzica, Giancarlo |
| المساهمون: | Neuroscience Institute Cavalieri-Ottolenghi, Physiologie de la reproduction et des comportements Nouzilly (PRC), Institut Français du Cheval et de l'Equitation Saumur (IFCE)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Università degli studi di Torino = University of Turin (UNITO), Universidad Nacional de Educación a Distancia (UNED) |
| المصدر: | ISSN: 2218-1989 ; Metabolites ; https://hal.science/hal-03423551Test ; Metabolites, 2021, 11 (7), pp.1-27. ⟨10.3390/metabo11070449⟩. |
| بيانات النشر: | HAL CCSD MDPI |
| سنة النشر: | 2021 |
| المجموعة: | Université François-Rabelais de Tours: HAL |
| مصطلحات موضوعية: | endocrine disruptor, dimorphism, obesity, kisspeptin, POMC, orexin, phytoestrogens, [SDV.TOX.TCA]Life Sciences [q-bio]/Toxicology/Toxicology and food chain, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism |
| الوصف: | International audience ; The phytoestrogen genistein (GEN) may interfere with permanent morphological changes in the brain circuits sensitive to estrogen. Due to the frequent use of soy milk in the neonatal diet, we aimed to study the effects of early GEN exposure on some physiological and reproductive parameters. Mice of both sexes from PND1 to PND8 were treated with GEN (50 mg/kg body weight, comparable to the exposure level in babies fed with soy-based formulas). When adult, we observed, in GEN-treated females, an advanced pubertal onset and an altered estrous cycle, and, in males, a decrease of testicle weight and fecal testosterone concentration. Furthermore, we observed an increase in body weight and altered plasma concentrations of metabolic hormones (leptin, ghrelin, triiodothyronine) limited to adult females. Exposure to GEN significantly altered kisspeptin and POMC immunoreactivity only in females and orexin immunoreactivity in both sexes. In conclusion, early postnatal exposure of mice to GEN determines long-term sex-specific organizational effects. It impairs the reproductive system and has an obesogenic effect only in females, which is probably due to the alterations of neuroendocrine circuits controlling metabolism; thus GEN, should be classified as a metabolism disrupting chemical |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-03423551; https://hal.science/hal-03423551Test; https://hal.science/hal-03423551/documentTest; https://hal.science/hal-03423551/file/2021%20Metabolites.pdfTest; WOS: 000676333500001 |
| DOI: | 10.3390/metabo11070449 |
| الإتاحة: | https://doi.org/10.3390/metabo11070449Test https://hal.science/hal-03423551Test https://hal.science/hal-03423551/documentTest https://hal.science/hal-03423551/file/2021%20Metabolites.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.D2293E25 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/metabo11070449 |
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