دورية أكاديمية
MARCH9‐mediated ubiquitination regulates MHC I export from the TGN
| العنوان: | MARCH9‐mediated ubiquitination regulates MHC I export from the TGN |
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| المؤلفون: | de Angelis Rigotti, Francesca, de Gassart, Aude, Pforr, Carina, Cano, Florencia, N'Guessan, Prudence, Combes, Alexis, Camossetto, Voahirana, Lehner, Paul, Gatti, Evelina, Pierre, Philippe, Rigotti, Angelis |
| المساهمون: | Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Addenbrookes Hospital, Centre Interuniversitaire de Recherche en Education de Lille - ULR 4354 (CIREL), Université de Lille, ANR-10-BLAN-1236,MARCHxIRAP,Rôle de l'ubiquitination dans la régulation du trafic intracellulaire des molécules de classe I du CMH et la présentation croisée(2010), ANR-11-LABX-0054,INFORM,Flux d'inFormation et organisation de la membrane(2011), ANR-11-LABX-0043,DCBIOL,Biologie des cellules dendritiques(2011), ANR-11-IDEX-0001,Amidex,INITIATIVE D'EXCELLENCE AIX MARSEILLE UNIVERSITE(2011) |
| المصدر: | ISSN: 0818-9641. |
| بيانات النشر: | HAL CCSD Nature Publishing Group |
| سنة النشر: | 2017 |
| المجموعة: | LillOA (HAL Lille Open Archive, Université de Lille) |
| مصطلحات موضوعية: | ubiquitin ligase, HLA, antigen presentation, dendritic cells, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Given the heterogeneous nature of antigens, MHC-I intracellular transport intersects with multiple degradation pathways for efficient peptide loading and presentation to cytotoxic T cells. MHC-I loading with peptides in the endoplasmic reticulum (ER) is a tightly regulated process, while postER intracellular transport is considered to occur by default, leading to peptide-bearing MHC-I delivery to the plasma membrane. We show here that MHC-I traffic is submitted to a previously uncharacterized sorting step at the trans Golgi network (TGN), dependent on the ubiquitination of its cytoplasmic tail lysine residues. MHC-I ubiquitination is mediated by the E3 ligase MARCH9 and allows MHC-I access to syntaxin 6 (Stx6)positive endosomal compartments. We further show that MARCH9 can also target the human MHC I-like lipid antigen presentation molecule CD1a. MARCH9 expression is modulated by microbial patterns exposure in dendritic cells (DC), thus revealing the role of this ubiquitin E3 ligase in coordinating MHC-I access to endosomes and DC activation for efficient antigen cross-presentation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-03545441; https://hal.science/hal-03545441Test; https://hal.science/hal-03545441/documentTest; https://hal.science/hal-03545441/file/Rigotti%202017%20final%20revised.pdfTest |
| DOI: | 10.1038/icb.2017.44 |
| الإتاحة: | https://doi.org/10.1038/icb.2017.44Test https://hal.science/hal-03545441Test https://hal.science/hal-03545441/documentTest https://hal.science/hal-03545441/file/Rigotti%202017%20final%20revised.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.D1F13F19 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/icb.2017.44 |
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